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Viral genome sequencing proves nosocomial transmission of fatal varicella.

Depledge, DP; Brown, J; Macanovic, J; Underhill, G; Breuer, J; (2016) Viral genome sequencing proves nosocomial transmission of fatal varicella. Journal of Infectious Diseases , 214 (9) pp. 1399-1402. 10.1093/infdis/jiw398. Green open access

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Abstract

We report the first use of whole viral genome sequencing to identify nosocomial transmission of varicella zoster virus with fatal outcome. The index case, nursed in source isolation, developed disseminated zoster with rash being present for one day prior to being transferred to the Intensive Care Unit. Two patients who had received renal transplants while inpatients in an adjacent ward, developed chickenpox and one died. In neither case was there direct contact with the index patient.

Type: Article
Title: Viral genome sequencing proves nosocomial transmission of fatal varicella.
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1093/infdis/jiw398
Publisher version: http://dx.doi.org/10.1093/infdis/jiw398
Language: English
Additional information: © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: fatal varicella; nosocomial transmission; whole genome sequencing;
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Infection and Immunity
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1518925
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