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Assessing morphology and function of the semicircular duct system: introducing new in-situ visualization and software toolbox

David, R; Stoessel, A; Berthoz, A; Spoor, F; Bennequin, D; (2016) Assessing morphology and function of the semicircular duct system: introducing new in-situ visualization and software toolbox. Scientific Reports , 6 , Article 32772. 10.1038/srep32772. Green open access

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Abstract

The semicircular duct system is part of the sensory organ of balance and essential for navigation and spatial awareness in vertebrates. Its function in detecting head rotations has been modelled with increasing sophistication, but the biomechanics of actual semicircular duct systems has rarely been analyzed, foremost because the fragile membranous structures in the inner ear are hard to visualize undistorted and in full. Here we present a new, easy-to-apply and non-invasive method for three-dimensional in-situ visualization and quantification of the semicircular duct system, using X-ray micro tomography and tissue staining with phosphotungstic acid. Moreover, we introduce Ariadne, a software toolbox which provides comprehensive and improved morphological and functional analysis of any visualized duct system. We demonstrate the potential of these methods by presenting results for the duct system of humans, the squirrel monkey and the rhesus macaque, making comparisons with past results from neurophysiological, oculometric and biomechanical studies. Ariadne is freely available at http://www.earbank.org.

Type: Article
Title: Assessing morphology and function of the semicircular duct system: introducing new in-situ visualization and software toolbox
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/srep32772
Publisher version: http://dx.doi.org/10.1038/srep32772
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Keywords: Science & Technology, Multidisciplinary Sciences, Science & Technology - Other Topics, 3-DIMENSIONAL RECONSTRUCTION, VESTIBULAR LABYRINTH, PLANAR RELATIONSHIPS, HEAD STABILIZATION, MATHEMATICAL-MODEL, CANAL MORPHOLOGY, SQUIRREL-MONKEY, INNER-EAR, DYNAMICS, LOCOMOTION
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL SLASH
UCL > Provost and Vice Provost Offices > UCL SLASH > Faculty of S&HS
UCL > Provost and Vice Provost Offices > UCL SLASH > Faculty of S&HS > Dept of Anthropology
URI: https://discovery.ucl.ac.uk/id/eprint/1516908
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