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Population-Level Effects of Human Papillomavirus Vaccination Programs on Infections with Nonvaccine Genotypes

Mesher, D; Soldan, K; Lehtinen, M; Beddows, S; Brisson, M; Brotherton, JML; Chow, EPF; ... Thomas, SL; + view all (2016) Population-Level Effects of Human Papillomavirus Vaccination Programs on Infections with Nonvaccine Genotypes. EMERGING INFECTIOUS DISEASES , 22 (10) pp. 1732-1740. 10.3201/eid2210.160675. Green open access

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Abstract

We analyzed human papillomavirus (HPV) prevalences during prevaccination and postvaccination periods to consider possible changes in nonvaccine HPV genotypes after introduction of vaccines that confer protection against 2 high-risk types, HPV16 and HPV18. Our meta-analysis included 9 studies with data for 13,886 girls and women ≤19 years of age and 23,340 women 20–24 years of age. We found evidence of cross-protection for HPV31 among the younger age group after vaccine introduction but little evidence for reductions of HPV33 and HPV45. For the group this same age group, we also found slight increases in 2 nonvaccine high-risk HPV types (HPV39 and HPV52) and in 2 possible high-risk types (HPV53 and HPV73). However, results between age groups and vaccines used were inconsistent, and the increases had possible alternative explanations; consequently, these data provided no clear evidence for type replacement. Continued monitoring of these HPV genotypes is important.

Type: Article
Title: Population-Level Effects of Human Papillomavirus Vaccination Programs on Infections with Nonvaccine Genotypes
Open access status: An open access version is available from UCL Discovery
DOI: 10.3201/eid2210.160675
Publisher version: http://dx.doi.org/0.3201/eid2210.160675
Language: English
Additional information: "Emerging Infectious Diseases is published by the Centers for Disease Control and Prevention, a U.S. Government agency. Therefore, materials published in Emerging Infectious Diseases, including text, figures, tables, and photographs are in the public domain and can be reprinted or used without permission with proper citation" - copyright statement via this link https://wwwnc.cdc.gov/eid/page/copyright-and-disclaimers
Keywords: Science & Technology, Life Sciences & Biomedicine, Immunology, Infectious Diseases, INVASIVE CERVICAL-CANCER, HPV-16/18 AS04-ADJUVANTED VACCINE, CROSS-PROTECTIVE EFFICACY, BLIND PATRICIA TRIAL, OF-STUDY ANALYSIS, INTRAEPITHELIAL NEOPLASIA, REPLACEMENT POSTVACCINATION, PARTICLE VACCINE, HERD-IMMUNITY, GENITAL WARTS
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute for Global Health > Infection and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1516717
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