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The impact of periodontal infection and its treatment on systemic inflammation, oxidative stress and endothelium integrity

Orlandi, M; (2016) The impact of periodontal infection and its treatment on systemic inflammation, oxidative stress and endothelium integrity. Doctoral thesis , UCL (University College London). Green open access

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Abstract

Background: Periodontitis (PD) is a chronic inflammatory disease. The low-grade systemic inflammatory and oxidative status seems to be a plausible mechanism to explain the relationship between cardiovascular disease (CVD) and PD. The aim of this PhD was to investigate the association between PD and its treatment and the human vascular homeostasis. Methods: 4 studies were conducted: 1) a systematic review and meta-analysis of cases with PD and controls to assess the differences in intima-media thickness and endothelial function between cases and controls, 2) a Randomized controlled trial investigating the effect of periodontal therapy on mitochondrial oxidative stress, systemic inflammation, endothelial function and metabolic control in patients with type II diabetes mellitus and periodontitis 3) a randomized controlled trial investigating the effect of periodontal treatment on the carotid intima media thickness 4) a RCT controlled trial investigating the effect of remote ischemic preconditioning on the endothelial dysfunction following periodontal treatment. Results: Study I demonstrated that there is an association between PD, flow mediated dilation and carotid intima media thickness, measures of cardiovascular risk. Study II reported the benefit of periodontal therapy on the endothelial function, mitochondrial oxidative stress and glycemic control in patients with Type 2 diabetes and PD. In Study III we reported the beneficial effect of periodontal treatment on the carotid intima-media thickness and lastly in Study IV demonstrated the protective effect of remote ischemic preconditioning toward the acute endothelial dysfunction following periodontal treatment. Conclusions: This PhD project provides evidence in support of the association between periodontitis and cardiovascular disease.

Type: Thesis (Doctoral)
Title: The impact of periodontal infection and its treatment on systemic inflammation, oxidative stress and endothelium integrity
Event: UCL
Open access status: An open access version is available from UCL Discovery
Language: English
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Restorative Dental Sciences
URI: https://discovery.ucl.ac.uk/id/eprint/1515839
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