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Phosphoinositide 3-kinase: a new kid on the block in vascular anomalies

Castillo, SD; Vanhaesebroeck, B; Sebire, NJ; (2016) Phosphoinositide 3-kinase: a new kid on the block in vascular anomalies. The Journal of Pathology , 240 (4) pp. 387-396. 10.1002/path.4802. Green open access

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Abstract

Vascular anomalies are broadly divided into vascular tumours and malformations. These lesions are composed of abnormal vascular elements of various types, and mainly affect infants, children, and young adults. Vascular anomalies may be painful, may be complicated by bleeding, infection, or organ dysfunction, and can have secondary effects on other tissues. Current treatment strategies include surgical excision, pulsed laser, and sclerotherapy, which are invasive, with risks of recurrence. There are growing pharmacological options for these vascular anomalies, but, to date, no specific targeted therapies have been developed. Phosphoinositide 3-kinases (PI3Ks) constitute a family of lipid kinases that are involved in signal transduction and vesicular traffic, and that modulate important cellular processes such as proliferation, growth, and migration. Recent findings have indicated that the PI3K signalling pathway is important in the pathogenesis of vascular anomalies. This provides an opportunity to use PI3K inhibitors, which are in clinical trials for cancer treatment, for such lesions. Here, we provide an update on the classification of vascular anomalies, with their major features, and discuss the role of the PI3K signalling pathway in the pathogenesis of vascular anomalies, and their clinical implications and therapeutic opportunities. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

Type: Article
Title: Phosphoinositide 3-kinase: a new kid on the block in vascular anomalies
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/path.4802
Publisher version: http://doi.org/10.1002/path.4802
Language: English
Additional information: Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. This is the peer reviewed version of the following article: Castillo, SD; Vanhaesebroeck, B; Sebire, NJ; (2016) Phosphoinositide 3-kinase: a new kid on the block in vascular anomalies. The Journal of Pathology 10.1002/path.4802, which has been published in final form at http://doi.org/10.1002/path.4802. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: AKT, PI3K, mTOR, signal transduction, targeted therapy, vascular anomaly, vascular malformation, vascular tumour
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > UCL GOS Institute of Child Health > ICH Pop, Policy and Practice Prog
URI: https://discovery.ucl.ac.uk/id/eprint/1514567
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