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Prediction of Clinical Scores from Neuroimaging Data with Censored Likelihood Gaussian Processes

Rao, A; Monteiro, J; Mourao-Miranda, J; (2016) Prediction of Clinical Scores from Neuroimaging Data with Censored Likelihood Gaussian Processes. In: Proceedings of 2016 International Workshop on Pattern Recognition in Neuroimaging (PRNI). (pp. pp. 129-132). IEEE: Trento, Italy. Green open access

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Abstract

In this paper, we explore the use of Censored Likelihoods in Gaussian Process Regression when predicting bounded clinical scores from neuroimaging data. The standard approach, which uses a Gaussian Likelihood, does not respect the fact that the clinical scores are bounded, and so may produce suboptimal models. Conversely, Censored Likelihoods explicitly model the restricted range of such clinical scores and carry this property through inference. We apply both the standard approach and the Censored Likelihood approach to the prediction of the MMSE score from structural MRI. Overall, we find small improvements in mean squared error when using the Censored Likelihood and in addition, the censored models are more favoured from a Bayesian perspective. We also discuss the qualitative nature of the predictions of the two approaches.

Type: Proceedings paper
Title: Prediction of Clinical Scores from Neuroimaging Data with Censored Likelihood Gaussian Processes
Event: 6th International Workshop on Pattern Recognition in Neuroimaging (PRNI) 2016
Location: Trento, ITALY
Dates: 22 June 2016 - 24 June 2016
Open access status: An open access version is available from UCL Discovery
Publisher version: https://doi.org/10.1109/PRNI.2016.7552358
Language: English
Additional information: Copyright © 2016 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.
Keywords: gaussian processes, clinical scores
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/1513292
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