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Periventricular lesions and MS diagnostic criteria in young adults with typical clinically isolated syndromes.

Brownlee, WJ; Miszkiel, KA; Altmann, DR; Ciccarelli, O; Miller, DH; (2016) Periventricular lesions and MS diagnostic criteria in young adults with typical clinically isolated syndromes. Multiple Sclerosis , 23 (7) pp. 1031-1034. 10.1177/1352458516667565. Green open access

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Abstract

In patients who present with a clinically isolated syndrome (CIS), whose features are suggestive of multiple sclerosis (MS), fulfilling McDonald 2010 magnetic resonance imaging (MRI) criteria for dissemination in space (DIS) and dissemination in time (DIT) enables a diagnosis of MS. While ⩾1 periventricular lesion is included in the 2010 DIS criteria, earlier McDonald criteria required ⩾3 periventricular lesions to confirm DIS and recent Magnetic Resonance Imaging in Multiple Sclerosis (MAGNIMS)-recommended DIS criteria also require ⩾3 lesions. We investigated the effect of varying the required number of periventricular lesions and found that the best combination of specificity and sensitivity for clinically definite MS was seen for ⩾1 periventricular lesion using both the McDonald 2010 and MAGNIMS 2016 criteria.

Type: Article
Title: Periventricular lesions and MS diagnostic criteria in young adults with typical clinically isolated syndromes.
Open access status: An open access version is available from UCL Discovery
DOI: 10.1177/1352458516667565
Publisher version: http://doi.org/10.1177/1352458516667565
Language: Croatian
Additional information: © The Author(s), 2016.
Keywords: Multiple sclerosis, clinically isolated syndrome, diagnostic criteria, magnetic resonance imaging
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1508307
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