Mulvany, MJ;
Videboek, LM;
Hughes, AD;
Aalkjoer, C;
(1990)
Mechanism of the Vasodilator Action of Pinacidil.
Blood Vessels
, 27
pp. 314-318.
10.1159/000158824.
Preview |
Text
Hughes_Mechanism of the Vasodilator Action of Pinacidil.pdf - Accepted version Download (250kB) | Preview |
Abstract
The mechanism of the vasodilator action of pinacidil has been studied in rat mesenteric small arteries. The results show, first, that the use of flux studies to make measurements of ion permeability requires knowledge of the membrane potential, especially as regards K+ permeability. Second, the results confirm that the vasodilator effect of pinacidil is due to an increase in K+ permeability. Lastly, the results suggest that the K+ channels involved are sensitive to glibenclamide.
Archive Staff Only
 |
View Item |
