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Mechanism of the Vasodilator Action of Pinacidil

Mulvany, MJ; Videboek, LM; Hughes, AD; Aalkjoer, C; (1990) Mechanism of the Vasodilator Action of Pinacidil. Blood Vessels , 27 pp. 314-318. 10.1159/000158824. Green open access

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Abstract

The mechanism of the vasodilator action of pinacidil has been studied in rat mesenteric small arteries. The results show, first, that the use of flux studies to make measurements of ion permeability requires knowledge of the membrane potential, especially as regards K+ permeability. Second, the results confirm that the vasodilator effect of pinacidil is due to an increase in K+ permeability. Lastly, the results suggest that the K+ channels involved are sensitive to glibenclamide.

Type: Article
Title: Mechanism of the Vasodilator Action of Pinacidil
Location: STRASBOURG, FRANCE
Open access status: An open access version is available from UCL Discovery
DOI: 10.1159/000158824
Publisher version: https://doi.org/10.1159/000158824
Language: English
Additional information: This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine
URI: https://discovery.ucl.ac.uk/id/eprint/1505524
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