Mulvany, MJ;
Videboek, LM;
Hughes, AD;
Aalkjoer, C;
(1990)
Mechanism of the Vasodilator Action of Pinacidil.
Blood Vessels
, 27
pp. 314-318.
10.1159/000158824.
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Abstract
The mechanism of the vasodilator action of pinacidil has been studied in rat mesenteric small arteries. The results show, first, that the use of flux studies to make measurements of ion permeability requires knowledge of the membrane potential, especially as regards K+ permeability. Second, the results confirm that the vasodilator effect of pinacidil is due to an increase in K+ permeability. Lastly, the results suggest that the K+ channels involved are sensitive to glibenclamide.
| Type: | Article |
|---|---|
| Title: | Mechanism of the Vasodilator Action of Pinacidil |
| Location: | STRASBOURG, FRANCE |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1159/000158824 |
| Publisher version: | https://doi.org/10.1159/000158824 |
| Language: | English |
| Additional information: | This version is the author accepted manuscript. For information on re-use, please refer to the publisher’s terms and conditions. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1505524 |
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