Temple, JL;
Cordero, P;
Li, J;
Vi, N;
Oben, JA;
(2016)
A Guide to Non-Alcoholic Fatty Liver Disease in Childhood and Adolescence.
International Journal of Molecular Sciences
, 17
(6)
, Article 947. 10.3390/ijms17060947.
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Abstract
Non-Alcoholic Fatty Liver Disease (NAFLD) is now the most prevalent form of chronic liver disease, affecting 10%–20% of the general paediatric population. Within the next 10 years it is expected to become the leading cause of liver pathology, liver failure and indication for liver transplantation in childhood and adolescence in the Western world. While our understanding of the pathophysiological mechanisms underlying this disease remains limited, it is thought to be the hepatic manifestation of more widespread metabolic dysfunction and is strongly associated with a number of metabolic risk factors, including insulin resistance, dyslipidaemia, cardiovascular disease and, most significantly, obesity. Despite this, ”paediatric” NAFLD remains under-studied, under-recognised and, potentially, undermanaged. This article will explore and evaluate our current understanding of NAFLD in childhood and adolescence and how it differs from adult NAFLD, in terms of its epidemiology, pathophysiology, natural history, diagnosis and clinical management. Given the current absence of definitive radiological and histopathological diagnostic tests, maintenance of a high clinical suspicion by all members of the multidisciplinary team in primary and specialist care settings remains the most potent of diagnostic tools, enabling early diagnosis and appropriate therapeutic intervention.
| Type: | Article |
|---|---|
| Title: | A Guide to Non-Alcoholic Fatty Liver Disease in Childhood and Adolescence |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.3390/ijms17060947 |
| Publisher version: | http://dx.doi.org/10.3390/ijms17060947 |
| Language: | English |
| Additional information: | Copyright © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Physical Sciences, Biochemistry & Molecular Biology, Chemistry, Multidisciplinary, Chemistry, NAFLD, steatosis, obesity, children, adolescent, RANDOMIZED CONTROLLED-TRIAL, METABOLIC SYNDROME CRITERIA, PLACEBO-CONTROLLED TRIAL, OBESE CHILDREN, HEPATIC STEATOSIS, URSODEOXYCHOLIC ACID, VITAMIN-E, INSULIN-RESISTANCE, BARIATRIC SURGERY, LIFE-STYLE |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1504678 |
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