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Escape from epigenetic silencing of lactase expression is triggered by a single-nucleotide change

Swallow, DM; Troelsen, JT; (2016) Escape from epigenetic silencing of lactase expression is triggered by a single-nucleotide change. Nature: Structural & Molecular Biology , 23 (6) pp. 505-507. 10.1038/nsmb.3238. Green open access

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Abstract

The importance of subtle gene regulation and epigenetics in determining complex human traits is increasingly being recognized. However, bridging the gaps between environmental, epigenetic and genetic influences and unraveling causal relationships remain a big challenge. A study now reports an example of epigenetic changes influenced by genetic factors that are involved in the regulation of lactase gene expression.

Type: Article
Title: Escape from epigenetic silencing of lactase expression is triggered by a single-nucleotide change
Open access status: An open access version is available from UCL Discovery
DOI: 10.1038/nsmb.3238
Publisher version: http://doi.org/10.1038/nsmb.3238
Language: English
Additional information: Copyright © 2016 Nature America, Inc. All rights reserved.
Keywords: DNA methylation, Genetics
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment
URI: https://discovery.ucl.ac.uk/id/eprint/1499842
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