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Treatment regimens for rifampicin-resistant tuberculosis: highlighting a research gap

Stagg, HR; Hatherell, HA; Lipman, MC; Harris, RJ; Abubakar, I; (2016) Treatment regimens for rifampicin-resistant tuberculosis: highlighting a research gap. International Journal of Tuberculosis and Lung Disease , 20 (7) pp. 866-869. 10.5588/ijtld.16.0034. Green open access

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Abstract

Treatment guidance for non-multidrug-resistant (MDR) rifampicin-resistant (RMP-R) tuberculosis (TB) is variable. We aimed to undertake a systematic review and meta-analysis of the randomised controlled trial (RCT) data behind such guidelines to identify the most efficacious treatment regimens. Ovid MEDLINE, the Web of Science and EMBASE were mined using search terms for TB, drug therapy and RCTs. Despite 12 604 records being retrieved, only three studies reported treatment outcomes by regimen for patients with non-MDR RMP-R disease, preventing meta-analysis. Our systematic review highlights a substantial gap in the literature regarding evidence-based treatment regimens for RMP-R TB.

Type: Article
Title: Treatment regimens for rifampicin-resistant tuberculosis: highlighting a research gap
Location: France
Open access status: An open access version is available from UCL Discovery
DOI: 10.5588/ijtld.16.0034
Publisher version: http://dx.doi.org/10.5588/ijtld.16.0034
Language: English
Additional information: Copyright © 2016 International Union Against Tuberculosis and Lung Disease (The Union). This is the accepted manuscript version of the article published in the International Journal of Tuberculosis and Lung Disease (IJTLD); the final published article is available at http://dx.doi.org/10.5588/ijtld.16.0034
Keywords: monoresistance; randomised controlled trials; systematic review
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Respiratory Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute for Global Health > Infection and Population Health
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
URI: https://discovery.ucl.ac.uk/id/eprint/1498684
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