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White Light-Activated Antimicrobial Paint using Crystal Violet

Hwang, GB; Allan, E; Parkin, IP; (2016) White Light-Activated Antimicrobial Paint using Crystal Violet. ACS Applied Materials and Interfaces , 8 (24) pp. 15033-15039. 10.1021/acsami.5b06927. Green open access

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Abstract

Crystal violet (CV) was incorporated into acrylic latex to produce white-light-activated antimicrobial paint (WLAAP). Measurement of the water contact angle of the WLAAP showed that the water contact angle increased with increasing CV concentration. In a leaching test over 120 h, the amount of CV that leached from the WLAAPs was close to the detection limit (<0.03%). The WLAAPs were used to coat samples of polyurethane, and these showed bactericidal activity against Escherichia coli, which is a key causative agent of healthcare-associated infections (HAIs). A reduction in the numbers of viable bacteria was observed on the painted coated polyurethane after 6 h in the dark, and the bactericidal activity increased with increasing CV concentration (P < 0.1). After 6 h of white light exposure, all of coated polyurethanes demonstrated a potent photobactericidal activity, and it was statistically confirmed that the WLAAP showed better activity in white light than in the dark (P < 0.05). At the highest CV concentration, the numbers of viable bacteria fell below the detection limit (<103 CFU/mL) after 6 h of white light exposure. The difference in antimicrobial activity between the materials in the light and dark was 0.48 log at CV 250 ppm, and it increased by 0.43 log at each increment of CV 250 ppm. The difference was the highest (>1.8 log) at the highest CV concentration (1000 ppm). These WLAAPs are promising candidates for use in healthcare facilities to reduce HAIs.

Type: Article
Title: White Light-Activated Antimicrobial Paint using Crystal Violet
Open access status: An open access version is available from UCL Discovery
DOI: 10.1021/acsami.5b06927
Publisher version: http://dx.doi.org/10.1021/acsami.5b06927
Language: English
Additional information: This version is the version of record. For information on re-use, please refer to the publisher’s terms and conditions.
Keywords: Science & Technology, Technology, Nanoscience & Nanotechnology, Materials Science, Multidisciplinary, Science & Technology - Other Topics, Materials Science, Crystal violet, acrylic latex, E. coil bacteria, white light-activated antimicrobial paint, water contact angle, Device-Associated Module, Safety Network Report, Silver Nanoparticles, Gentian-Violet, Methylene-Blue, Surface Functionalization, Bacterial-Contamination, Staphylococcus-Aureus, Photodynamic Therapy, Gold Nanoparticles
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute > Microbial Diseases
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1497078
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