Scalco, RS;
Voermans, NC;
Piercy, RJ;
Jungbluth, H;
Quinlivan, R;
(2016)
Dantrolene as a possible prophylactic treatment for RYR1-related rhabdomyolysis.
European Journal of Neurology
, 23
(8)
e56-e57.
10.1111/ene.13051.
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Abstract
Rhabdomyolysis (RM) may result from gene-environment interactions (1). Mutations in RYR1 lead to various neuromuscular phenotypes including malignant hyperthermia susceptibility and RM (2, 3). Preventive measures specifically aimed at RYR1-related RM mainly consist of avoidance of known triggers such as exercising in hot environments and untreated pyrexia. We report use of oral dantrolene as a prophylactic treatment for RYR1- related RM in three severely affected patients (patient consent was obtained for case report publication) (Table 1).
| Type: | Article |
|---|---|
| Title: | Dantrolene as a possible prophylactic treatment for RYR1-related rhabdomyolysis |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1111/ene.13051 |
| Publisher version: | http://dx.doi.org/10.1111/ene.13051 |
| Language: | English |
| Additional information: | This is the peer reviewed version of the following article: Scalco, RS; Voermans, NC; Piercy, RJ; Jungbluth, H; Quinlivan, R; (2016) Dantrolene as a possible prophylactic treatment for RYR1-related rhabdomyolysis. European Journal of Neurology, 23 (8) e56-e57, which has been published in final form at: http://dx.doi.org/10.1111/ene.13051. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving (http://olabout.wiley.com/WileyCDA/Section/id-828039.html#terms). |
| Keywords: | Dantrolene, RYR1, RYR1 Dantrolene, Myoglobinuria, RYR1 Treatment, RYR1 Prophylaxis, Rhabdomyolysis Prophylaxis, Rhabdomyolysis Treatment |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1496881 |
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