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Hypomethylation of FAM63B in bipolar disorder patients

Starnawska, A; Demontis, D; McQuillin, A; O'Brien, NL; Staunstrup, NH; Mors, O; Nielsen, AL; ... Nyegaard, M; + view all (2016) Hypomethylation of FAM63B in bipolar disorder patients. Clinical Epigenetics , 8 , Article ARTN 52. 10.1186/s13148-016-0221-6. Green open access

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Abstract

Bipolar disorder (BD) and schizophrenia (SZ) are known to share common genetic and psychosocial risk factors. A recent epigenome-wide association study performed on blood samples from SZ patients found significant hypomethylation of FAM63B in exon 9. Here, we used iPLEX-based methylation analysis to investigate two CpG sites in FAM63B in blood samples from 459 BD cases and 268 controls. Both sites were significantly hypomethylated in BD cases (lowest p value = 3.94 × 10−8). The methylation levels at the two sites were correlated, and no strong correlation was found with nearby single nucleotide polymorphisms (SNPs), suggesting that methylation differences at these sites are not readably picked up by genome-wide association studies. Overall, FAM63B hypomethylation was found in BD patients, thus replicating the initial finding in SZ patients. This study suggests that FAM63B is a shared epigenetic risk gene for the two disorders.

Type: Article
Title: Hypomethylation of FAM63B in bipolar disorder patients
Open access status: An open access version is available from UCL Discovery
DOI: 10.1186/s13148-016-0221-6
Publisher version: http://dx.doi.org/10.1186/s13148-016-0221-6
Language: English
Additional information: © Starnawska et al. 2016 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Keywords: Science & Technology, Life Sciences & Biomedicine, Oncology, Epigenetics, DNA methylation, Candidate gene, Mental disorder, iPLEX, FAM63B, Bipolar disorder, WHOLE-GENOME ASSOCIATION, WIDE ASSOCIATION, DNA METHYLATION, SCHIZOPHRENIA, SIGNATURES, EXPRESSION, PSYCHOSIS, GENETICS, PROJECT, LOCI
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Division of Psychiatry
URI: https://discovery.ucl.ac.uk/id/eprint/1494157
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