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Molecular engineering of polymersome surface topology

Ruiz-Perez, L; Messager, L; Gaitzsch, J; Joseph, A; Sutto, L; Gervasio, FL; Battaglia, G; (2016) Molecular engineering of polymersome surface topology. Science Advances , 2 (4) , Article e1500948. 10.1126/sciadv.1500948. Green open access

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Abstract

Biological systems exploit self-assembly to create complex structures whose arrangements are finely controlled from the molecular to mesoscopic level. We report an example of using fully synthetic systems that mimic two levels of self-assembly. We show the formation of vesicles using amphiphilic copolymers whose chemical nature is chosen to control both membrane formation and membrane-confined interactions. We report polymersomes with patterns that emerge by engineering interfacial tension within the polymersome surface. This allows the formation of domains whose topology is tailored by chemical synthesis, paving the avenue to complex supramolecular designs functionally similar to those found in viruses and trafficking vesicles.

Type: Article
Title: Molecular engineering of polymersome surface topology
Open access status: An open access version is available from UCL Discovery
DOI: 10.1126/sciadv.1500948
Publisher version: http://dx.doi.org/10.1126/sciadv.1500948
Language: English
Additional information: Copyright © 2016, The Authors. This is an open-access article distributed under the terms of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keywords: Controlled self-assembly, block copolymers, vesicles, surface topology, biomimetic structures
UCL classification: UCL
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Chemistry
URI: https://discovery.ucl.ac.uk/id/eprint/1493343
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