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Rapid processing of PET list-mode data for efficient uncertainty estimation and data analysis

Markiewicz, PJ; Thielemans, K; Schott, JM; Atkinson, D; Arridge, S; Hutton, B; Ourselin, S; (2016) Rapid processing of PET list-mode data for efficient uncertainty estimation and data analysis. Physics in Medicine and Biology , 61 (13) N322-N336. 10.1088/0031-9155/61/13/N322. Green open access

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Abstract

In this technical note we propose a rapid and scalable software solution for the processing of PET list-mode data, which allows the efficient integration of list mode data processing into the workflow of image reconstruction and analysis. All processing is performed on the graphics processing unit (GPU), making use of streamed and concurrent kernel execution together with data transfers between disk and CPU memory as well as CPU and GPU memory. This approach leads to fast generation of multiple bootstrap realisations, and when combined with fast image reconstruction and analysis, it enables assessment of uncertainties of any image statistic and of any component of the image generation process (e.g., random correction, image processing) within reasonable time frames (e.g., within five minutes per realisation). This is of particular value when handling complex chains of image generation and processing. The software outputs the following: (1) estimate of expected random event data for noise reduction; (2) dynamic prompt and random sinograms of span-1 and span-11 and (3) variance estimates based on multiple bootstrap realisations of (1) and (2) assuming reasonable count levels for acceptable accuracy. In addition, the software produces statistics and visualisations for immediate quality control and crude motion detection, such as: (1) count rate curves; (2) centre of mass plots of the radiodistribution for motion detection; (3) video of dynamic projection views for fast visual list-mode skimming and inspection; (4) full normalisation factor sinograms. To demonstrate the software, we present an example of the above processing for fast uncertainty estimation of regional SUVR (standard uptake value ratio) calculation for a single PET scan of ¹⁸F-florbetapir using the Siemens Biograph mMR scanner.

Type: Article
Title: Rapid processing of PET list-mode data for efficient uncertainty estimation and data analysis
Location: UK
Open access status: An open access version is available from UCL Discovery
DOI: 10.1088/0031-9155/61/13/N322
Publisher version: http://dx.doi.org/10.1088/0031-9155/61/13/N322
Language: English
Additional information: Copyright © 2016 Institute of Physics and Engineering in Medicine. Original content from this work may be used under the terms of the Creative Commons Attribution 3.0 licence (http://creativecommons.org/licenses/by/3.0/). The published article is available from the journal website at http://dx.doi.org/10.1088/0031-9155/61/13/N322
Keywords: posistron emission tomography, graphics processing unit, list mode, motion detection, projection views, histogramming, fast data processing
UCL classification: UCL
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UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
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UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neurodegenerative Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
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UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Experimental and Translational Medicine
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UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1492848
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