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Investigation of brain tumour metabolism using naturally occurring chemical exchange saturation transfer agents with magnetic resonance imaging

Torrealdea, F; (2016) Investigation of brain tumour metabolism using naturally occurring chemical exchange saturation transfer agents with magnetic resonance imaging. Doctoral thesis , UCL (University College London). Green open access

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Abstract

This thesis presents a thorough study on the newly developed glucoCEST magnetic resonance imaging (MRI) technique and its application for the assessment of malignant brain tumours. The key asset of glucoCEST is that it allows the detection of small concentration of glucose with standard MRI scanners and has the potential to provide a novel imaging tool to investigate diseases in which glucose metabolism is affected, in particular cancer. The physical principles and the rationale behind the glucoCEST technique are described in detail and factors influencing the measurements (both physiological and hardware related) are analysed using computer simulations and evaluated with in vitro experiments. Special attention is given to the analysis of the first four sugars along the glycolytic pathway i.e. glucose, glucose 6-phosphate, fructose 6-phosphate and fructose 1,6-biphosphate as contributors to the overall observed signal. The results of this analysis give grounds for the argument of the intracellular origin of the glucoCEST signal, which opens the possibility of characterising tumours based on their metabolism with MRI. A preclinical glucoCEST study on mice bearing human xenograft glioblastoma is also presented in which cancers with diverse phenotype are scanned longitudinally throughout the different stages of tumour development. While not conclusive, the results suggest that the glucoCEST technique is able to identify the presence of cancer at an earlier stage than standard MRI methods.

Type: Thesis (Doctoral)
Title: Investigation of brain tumour metabolism using naturally occurring chemical exchange saturation transfer agents with magnetic resonance imaging
Event: UCL
Open access status: An open access version is available from UCL Discovery
Language: English
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Metabolism and Experi Therapeutics
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Neonatology
URI: https://discovery.ucl.ac.uk/id/eprint/1490928
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