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White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies

Burns, AJ; Goldstein, AM; Newgreen, DF; Stamp, L; Schaefer, K-H; Metzger, M; Hotta, R; ... Vanden Berghe, P; + view all (2016) White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies. Developmental Biology , 417 (2) pp. 229-251. 10.1016/j.ydbio.2016.04.001. Green open access

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Abstract

Over the last 20 years, there has been increasing focus on the development of novel stem cell based therapies for the treatment of disorders and diseases affecting the enteric nervous system (ENS) of the gastrointestinal tract (so-called enteric neuropathies). Here, the idea is that ENS progenitor/stem cells could be transplanted into the gut wall to replace the damaged or absent neurons and glia of the ENS. This White Paper sets out experts’ views on the commonly used methods and approaches to identify, isolate, purify, expand and optimize ENS stem cells, transplant them into the bowel, and assess transplant success, including restoration of gut function. We also highlight obstacles that must be overcome in order to progress from successful preclinical studies in animal models to ENS stem cell therapies in the clinic.

Type: Article
Title: White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies
Location: Rotterdam, NETHERLANDS
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.ydbio.2016.04.001
Publisher version: http://dx.doi.org/10.1016/j.ydbio.2016.04.001
Language: English
Additional information: © 2016 The Author. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
Keywords: Science & Technology, Life Sciences & Biomedicine, Developmental Biology, Enteric Nervous System, Enteric Neuropathies, Stem Cells, Cell Replacement Therapy, Hirschsprung Disease, Neural Crest Cells, Hypertrophic Pyloric-Stenosis, Hirschsprung Disease Liability, Slow-Transit Constipation, Rat Myenteric Plexus, Oxide Synthase Gene, Term-Follow-Up, Nitric-Oxide, In-Vivo, Intestinal Pseudoobstruction
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Biology and Cancer Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1489378
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