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Tissue Engineered Airways: A Prospects Article

Bogan, SL; Teoh, GZ; Birchall, MA; (2016) Tissue Engineered Airways: A Prospects Article. Journal of Cellular Biochemistry , 117 (7) pp. 1497-1505. 10.1002/jcb.25512. Green open access

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Abstract

An ideal tracheal scaffold must withstand luminal collapse yet be flexible, have a sufficient degree of porosity to permit vascular and cellular ingrowth, but also be airtight and must facilitate growth of functional airway epithelium to avoid infection and aid in mucocilliary clearance. Finally, the scaffold must also be biocompatible to avoid implant rejection. Over the last 40 years, efforts to design and manufacture the airway have been undertaken worldwide but success has been limited and far apart. As a result, tracheal resection with primary repair remains the Gold Standard of care for patients presenting with airway disorders and malignancies. However, the maximum resectable length of the trachea is restricted to 30% of the total length in children or 50% in adults. Attempts to provide autologous grafts for human application have also been disappointing for a host of different reasons, including lack of implant integration, insufficient donor organs and poor mechanical strength resulting in an unmet clinical need. The two main approaches researchers have taken to address this issue have been the development of synthetic scaffolds and the use of decellularised organs. To date, a number of different decellularisation techniques and a variety of materials, including polyglycolic acid (PGA) and nanocomposite polymers have been explored. The findings thus far have shown great promise, however there remain a significant number of caveats accompanying each approach. That being said, the possibilities presented by these two approaches could be combined to produce a highly successful, clinically viable hybrid scaffold. This article aims to highlight advances in airway tissue engineering and provide an overview of areas to explore and utilise in accomplishing the aim of a developing an ideal tracheal prosthesis.

Type: Article
Title: Tissue Engineered Airways: A Prospects Article
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/jcb.25512
Publisher version: http://doi.org/10.1002/jcb.25512
Language: English
Additional information: © 2016 Wiley Periodicals, Inc. This is the peer reviewed version of the following article: Bogan, SL; Teoh, GZ; Birchall, MA; (2016) Tissue Engineered Airways: A Prospects Article. Journal of Cellular Biochemistry, 117 (7) pp. 1497-1505, which has been published in final form at http://dx.doi.org/10.1002/jcb.25512. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
Keywords: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Cell Biology, AIRWAY, STEM CELLS, HYBRID SCAFFOLDS, TISSUE ENGINEERING, REGENERATIVE MEDICINE, EPITHELIAL REGENERATION, BIODEGRADABLE POLYMERS, TRACHEAL REPLACEMENT, IN-VITRO, TRANSPLANTATION, CHONDROCYTES, GRAFT, RECONSTRUCTION, NANOCOMPOSITE, FIBROBLASTS
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Surgical Biotechnology
URI: https://discovery.ucl.ac.uk/id/eprint/1483606
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