Hunt, LT;
Behrens, TEJ;
Hosokawa, T;
Wallis, JD;
Kennerley, SW;
(2015)
Capturing the temporal evolution of choice across prefrontal cortex.
eLIFE
, 4
, Article e11945. 10.7554/eLife.11945.
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Abstract
Activity in prefrontal cortex (PFC) has been richly described using economic models of choice. Yet such descriptions fail to capture the dynamics of decision formation. Describing dynamic neural processes has proven challenging due to the problem of indexing the internal state of PFC and its trial-by-trial variation. Using primate neurophysiology and human magnetoencephalography, we here recover a single-trial index of PFC internal states from multiple simultaneously recorded PFC subregions. This index can explain the origins of neural representations of economic variables in PFC. It describes the relationship between neural dynamics and behaviour in both human and monkey PFC, directly bridging between human neuroimaging data and underlying neuronal activity. Moreover, it reveals a functionally dissociable interaction between orbitofrontal cortex, anterior cingulate cortex and dorsolateral PFC in guiding cost-benefit decisions. We cast our observations in terms of a recurrent neural network model of choice, providing formal links to mechanistic dynamical accounts of decision-making.
| Type: | Article |
|---|---|
| Title: | Capturing the temporal evolution of choice across prefrontal cortex |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.7554/eLife.11945 |
| Publisher version: | http://doi.org/10.7554/eLife.11945 |
| Language: | English |
| Additional information: | Copyright Hunt et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, ANTERIOR CINGULATE CORTEX, OPTIMAL DECISION-MAKING, FRONTAL-CORTEX, PARIETAL CORTEX, MOTOR CORTEX, ORBITOFRONTAL CORTEX, INTERTEMPORAL CHOICE, DOUBLE DISSOCIATION, ECONOMIC DECISIONS, VALUE COMPUTATIONS |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1483385 |
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