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The formation and function of ER-endosome membrane contact sites

Eden, ER; (2016) The formation and function of ER-endosome membrane contact sites. Biochimica et Biophysica Acta , 1861 (8, B) pp. 874-879. 10.1016/j.bbalip.2016.01.020. Green open access

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Abstract

Recent advances in membrane contact site (MCS) biology have revealed key roles for MCSs in inter-organellar exchange, the importance of which is becoming increasingly apparent. Roles for MCSs in many essential physiological processes including lipid transfer, calcium exchange, receptor tyrosine kinase signalling, lipid droplet formation, autophagosome formation, organelle dynamics and neurite outgrowth have been reported. The ER forms an extensive and dynamic network of MCSs with a diverse range of functionally distinct organelles. MCSs between the ER and endocytic pathway are particularly abundant, suggesting important physiological roles. Here, our current knowledge of the formation and function of ER contact sites with endocytic organelles from studies in mammalian systems is reviewed. Their relatively poorly defined molecular composition and recently identified functions are discussed. In addition, likely, but yet to be established, roles for these contacts in lipid transfer and calcium signalling are considered. This article is part of a Special Issue entitled: The cellular lipid landscape edited by Tim Levine and Anant K. Menon.

Type: Article
Title: The formation and function of ER-endosome membrane contact sites
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.bbalip.2016.01.020
Publisher version: http://dx.doi.org/10.1016/j.bbalip.2016.01.020
Language: English
Additional information: © 2016 The Author. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Endoplasmic reticulum, Endosome, Lipid transport, Membrane contact site
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
URI: https://discovery.ucl.ac.uk/id/eprint/1482860
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