UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Matrin3: connecting gene expression with the nuclear matrix

Coelho, MB; Attig, J; Ule, J; Smith, CW; (2016) Matrin3: connecting gene expression with the nuclear matrix. Wiley Interdisciplinary Reviews: RNA , 7 (3) pp. 303-315. 10.1002/wrna.1336. Green open access

[thumbnail of Coelho et al Matrin3 - connecting gene expression with the nuclear matrix.pdf]
Preview
Text
Coelho et al Matrin3 - connecting gene expression with the nuclear matrix.pdf

Download (454kB) | Preview

Abstract

As indicated by its name, Matrin3 was discovered as a component of the nuclear matrix, an insoluble fibrogranular network that structurally organizes the nucleus. Matrin3 possesses both DNA- and RNA-binding domains and, consistent with this, has been shown to function at a number of stages in the life cycle of messenger RNAs. These numerous activities indicate that Matrin3, and indeed the nuclear matrix, do not just provide a structural framework for nuclear activities but also play direct functional roles in these activities. Here, we review the structure, functions, and molecular interactions of Matrin3 and of Matrin3-related proteins, and the pathologies that can arise upon mutation of Matrin3.

Type: Article
Title: Matrin3: connecting gene expression with the nuclear matrix
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/wrna.1336
Publisher version: http://dx.doi.org/10.1002/wrna.1336
Language: English
Additional information: © 2016 Wiley Periodicals, Inc. This is the pre-peer reviewed version of the following article: [Coelho, M. B., Attig, J., Ule, J. and Smith, C. W.J. (2016), Matrin3: connecting gene expression with the nuclear matrix. WIREs RNA, 7: 303–315. doi: 10.1002/wrna.1336], which has been published in final form at http://dx.doi.org/10.1002/wrna.1336. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
URI: https://discovery.ucl.ac.uk/id/eprint/1482377
Downloads since deposit
127Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item