Coelho, MB;
Attig, J;
Ule, J;
Smith, CW;
(2016)
Matrin3: connecting gene expression with the nuclear matrix.
Wiley Interdisciplinary Reviews: RNA
, 7
(3)
pp. 303-315.
10.1002/wrna.1336.
Preview |
Text
Coelho et al Matrin3 - connecting gene expression with the nuclear matrix.pdf Download (454kB) | Preview |
Abstract
As indicated by its name, Matrin3 was discovered as a component of the nuclear matrix, an insoluble fibrogranular network that structurally organizes the nucleus. Matrin3 possesses both DNA- and RNA-binding domains and, consistent with this, has been shown to function at a number of stages in the life cycle of messenger RNAs. These numerous activities indicate that Matrin3, and indeed the nuclear matrix, do not just provide a structural framework for nuclear activities but also play direct functional roles in these activities. Here, we review the structure, functions, and molecular interactions of Matrin3 and of Matrin3-related proteins, and the pathologies that can arise upon mutation of Matrin3.
| Type: | Article |
|---|---|
| Title: | Matrin3: connecting gene expression with the nuclear matrix |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1002/wrna.1336 |
| Publisher version: | http://dx.doi.org/10.1002/wrna.1336 |
| Language: | English |
| Additional information: | © 2016 Wiley Periodicals, Inc. This is the pre-peer reviewed version of the following article: [Coelho, M. B., Attig, J., Ule, J. and Smith, C. W.J. (2016), Matrin3: connecting gene expression with the nuclear matrix. WIREs RNA, 7: 303–315. doi: 10.1002/wrna.1336], which has been published in final form at http://dx.doi.org/10.1002/wrna.1336. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1482377 |
Archive Staff Only
 |
View Item |
