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Millisecond Coupling of Local Field Potentials to Synaptic Currents in the Awake Visual Cortex

Haider, B; Schulz, DP; Häusser, M; Carandini, M; (2016) Millisecond Coupling of Local Field Potentials to Synaptic Currents in the Awake Visual Cortex. Neuron , 90 (1) pp. 35-42. 10.1016/j.neuron.2016.02.034. Green open access

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Abstract

The cortical local field potential (LFP) is a common measure of population activity, but its relationship to synaptic activity in individual neurons is not fully established. This relationship has been typically studied during anesthesia and is obscured by shared slow fluctuations. Here, we used patch-clamp recordings in visual cortex of anesthetized and awake mice to measure intracellular activity; we then applied a simple method to reveal its coupling to the simultaneously recorded LFP. LFP predicted membrane potential as accurately as synaptic currents, indicating a major role for synaptic currents in the relationship between cortical LFP and intracellular activity. During anesthesia, cortical LFP predicted excitation far better than inhibition; during wakefulness, it predicted them equally well, and visual stimulation further enhanced predictions of inhibition. These findings reveal a central role for synaptic currents, and especially inhibition, in the relationship between the subthreshold activity of individual neurons and the cortical LFP during wakefulness.

Type: Article
Title: Millisecond Coupling of Local Field Potentials to Synaptic Currents in the Awake Visual Cortex
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.neuron.2016.02.034
Publisher version: http://dx.doi.org/10.1016/j.neuron.2016.02.034
Language: English
Additional information: Copyright © 2016 The Authors This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). This document was posted here by permission of the publisher. At the time of the deposit, it included all changes made during peer review, copy editing, and publishing. The U. S. National Library of Medicine is responsible for all links within the document and for incorporating any publisher-supplied amendments or retractions issued subsequently. The published journal article, guaranteed to be such by Elsevier, is available for free, on ScienceDirect, at: http://dx.doi.org/10.1016/j.neuron.2016.02.034
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Wolfson Inst for Biomedical Research
URI: https://discovery.ucl.ac.uk/id/eprint/1481795
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