Harfield, C;
Fury, CR;
Memoli, G;
Jones, P;
Ovenden, N;
Stride, E;
(2016)
Analysis of the Uncertainty in Microbubble Characterization.
Ultrasound in Medicine and Biology
, 42
(6)
pp. 1412-1418.
10.1016/j.ultrasmedbio.2016.01.005.
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Abstract
There is increasing interest in the use of microbubble contrast agents for quantitative imaging applications such as perfusion and blood pressure measurement. The response of a microbubble to ultrasound excitation is, however, extremely sensitive to its size, the properties of its coating and the characteristics of the sound field and surrounding environment. Hence the results of microbubble characterization experiments can be significantly affected by experimental uncertainties, and this can limit their utility in predictive modelling. The aim of this study was to attempt to quantify these uncertainties and their influence upon measured microbubble characteristics. Estimates for the parameters characterizing the microbubble coating were obtained by fitting model data to numerical simulations of microbubble dynamics. The effect of uncertainty in different experimental parameters was gauged by modifying the relevant input values to the fitting process. The results indicate that even the minimum expected uncertainty in, for example, measurements of microbubble radius using conventional optical microscopy, leads to variations in the estimated coating parameters of ∼20%. This should be taken into account in designing microbubble characterization experiments and in the use of data obtained from them.
| Type: | Article |
|---|---|
| Title: | Analysis of the Uncertainty in Microbubble Characterization |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.ultrasmedbio.2016.01.005 |
| Publisher version: | http://doi.org/10.1016/j.ultrasmedbio.2016.01.005 |
| Language: | English |
| Additional information: | Copyright © 2016 Elsevier Inc. This is an Open Access article made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/licenses/by/4.0 Access may be initially restricted by the publisher. |
| Keywords: | Microbubbles; Ultrasound contrast agent; Characterization; Modelling; Quantitative imaging; Uncertainty; Experimental error |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Mathematics UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1481734 |
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