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Duration of depressive symptoms and mortality risk: the English Longitudinal Study of Ageing (ELSA)

White, J; Zaninotto, P; Walters, K; Kivimaeki, M; Demakakos, P; Biddulph, J; Kumari, M; ... Batty, GD; + view all (2016) Duration of depressive symptoms and mortality risk: the English Longitudinal Study of Ageing (ELSA). British Journal Of Psychiatry , 208 (4) pp. 337-342. 10.1192/bjp.bp.114.155333. Green open access

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Abstract

Background The relationship between the duration of depressive symptoms and mortality remains poorly understood. Aims To examine whether the duration of depressive symptoms is associated with mortality risk. Method Data (n = 9560) came from the English Longitudinal Study of Ageing (ELSA). We assessed depressive symptom duration as the sum of examinations with an eight-item Center for Epidemiologic Studies Depression Scale score of ⩾3; we ascertained mortality from linking our data to a national register. Results Relative to those participants who never reported symptoms, the age- and gender-adjusted hazard ratios for elevated depressive symptoms over 1, 2, 3 and 4 examinations were 1.41 (95% CI 1.15–1.74), 1.80 (95% CI 1.44–2.26), 1.97 (95% CI 1.57–2.47) and 2.48 (95% CI 1.90–3.23), respectively (P for trend <0.001). This graded association can be explained largely by differences in physical activity, cognitive function, functional impairments and physical illness. Conclusions In this cohort of older adults, the duration of depressive symptoms was associated with mortality in a dose–response manner.

Type: Article
Title: Duration of depressive symptoms and mortality risk: the English Longitudinal Study of Ageing (ELSA)
Open access status: An open access version is available from UCL Discovery
DOI: 10.1192/bjp.bp.114.155333
Publisher version: http://doi.org/10.1192/bjp.bp.114.155333
Language: English
Additional information: Copyright © The Royal College of Psychiatrists 2016. This is an open access article distributed under the terms of the Creative Commons Non-Commercial, No Derivatives (CC BY-NC-ND) licence.
Keywords: Science & Technology, Life Sciences & Biomedicine, Psychiatry, Older-adults, Cohort Profile, Disability, Health, Community, Life, Age
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Epidemiology and Public Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Epidemiology and Health > Primary Care and Population Health
URI: https://discovery.ucl.ac.uk/id/eprint/1480999
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