Karmin, M;
Saag, L;
Vicente, M;
Sayres, MAW;
Jarve, M;
Talas, UG;
Rootsi, S;
... Kivisild, T; + view all
(2015)
A recent bottleneck of Y chromosome diversity coincides with a global change in culture.
Genome Research
, 25
(4)
pp. 459-466.
10.1101/gr.186684.114.
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Abstract
It is commonly thought that human genetic diversity in non-African populations was shaped primarily by an out-of-Africa dispersal 50–100 thousand yr ago (kya). Here, we present a study of 456 geographically diverse high-coverage Y chromosome sequences, including 299 newly reported samples. Applying ancient DNA calibration, we date the Y-chromosomal most recent common ancestor (MRCA) in Africa at 254 (95% CI 192–307) kya and detect a cluster of major non-African founder haplogroups in a narrow time interval at 47–52 kya, consistent with a rapid initial colonization model of Eurasia and Oceania after the out-of-Africa bottleneck. In contrast to demographic reconstructions based on mtDNA, we infer a second strong bottleneck in Y-chromosome lineages dating to the last 10 ky. We hypothesize that this bottleneck is caused by cultural changes affecting variance of reproductive success among males.
| Type: | Article |
|---|---|
| Title: | A recent bottleneck of Y chromosome diversity coincides with a global change in culture |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1101/gr.186684.114 |
| Publisher version: | http://dx.doi.org/10.1101/gr.186684.114 |
| Language: | English |
| Additional information: | © 2015 Karmin et al.; Published by Cold Spring Harbor Laboratory Press This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genome.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Biotechnology & Applied Microbiology, Genetics & Heredity, Human Genome, Southern Route, Population, Tree, Sequence, Africa, Resolution, Haplogroups, Agriculture, Expansions |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Genetics, Evolution and Environment UCL > Provost and Vice Provost Offices > UCL SLASH UCL > Provost and Vice Provost Offices > UCL SLASH > Faculty of S&HS UCL > Provost and Vice Provost Offices > UCL SLASH > Faculty of S&HS > Dept of Anthropology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1479813 |
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