Owen, J;
Rademeyer, P;
Chung, D;
Cheng, Q;
Holroyd, D;
Coussios, C;
Friend, P;
... Stride, E; + view all
(2015)
Magnetic targeting of microbubbles against physiologically relevant flow conditions.
Interface Focus
, 5
(5)
, Article 20150001. 10.1098/rsfs.2015.0001.
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Abstract
The localization of microbubbles to a treatment site has been shown to be essential to their effectiveness in therapeutic applications such as targeted drug delivery and gene therapy. A variety of different strategies for achieving localization has been investigated, including biochemical targeting, acoustic radiation force, and the incorporation of superparamagnetic nanoparticles into microbubbles to enable their manipulation using an externally applied magnetic field. The third of these strategies has the advantage of concentrating microbubbles in a target region without exposing them to ultrasound, and can be used in conjunction with biochemical targeting to achieve greater specificity. Magnetic microbubbles have been shown to be effective for therapeutic delivery in vitro and in vivo. Whether this technique can be successfully applied in humans however remains an open question. The aim of this study was to determine the range of flow conditions under which targeting could be achieved. In vitro results indicate that magnetic microbubbles can be retained using clinically acceptable magnetic fields, for both the high shear rates (approx. 104 s−1) found in human arterioles and capillaries, and the high flow rates (approx. 3.5 ml s−1) of human arteries. The potential for human in vivo microbubble retention was further demonstrated using a perfused porcine liver model.
| Type: | Article |
|---|---|
| Title: | Magnetic targeting of microbubbles against physiologically relevant flow conditions |
| Location: | Chicheley, ENGLAND |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1098/rsfs.2015.0001 |
| Publisher version: | http://dx.doi.org/10.1098/rsfs.2015.0001 |
| Language: | English |
| Additional information: | © 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
| Keywords: | Science & Technology, Life Sciences & Biomedicine, Biology, Life Sciences & Biomedicine - Other Topics, microbubbles, magnetic targeting, ultrasound, drug delivery, contrast agent, imaging, Ultrasound Contrast Agents, Drug-Delivery, Gene Delivery, In-Vitro, Porcine Liver, Cancer, Microspheres, Doxorubicin, Release, Force |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1479053 |
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