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Interventional multispectral photoacoustic imaging with a clinical linear array ultrasound probe for guiding nerve blocks

Xia, W; West, SJ; Nikitichev, DI; Ourselin, S; Beard, PC; Desjardins, AE; (2016) Interventional multispectral photoacoustic imaging with a clinical linear array ultrasound probe for guiding nerve blocks. In: Oraevsky, AA and Wang, LV, (eds.) Photons Plus Ultrasound: Imaging and Sensing 2016. (pp. 97080C1-97080C6). Society of Photo-Optical Instrumentation Engineers: Washington, WA, United States. Green open access

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Abstract

Accurate identification of tissue structures such as nerves and blood vessels is critically important for interventional procedures such as nerve blocks. Ultrasound imaging is widely used as a guidance modality to visualize anatomical structures in real-time. However, identification of nerves and small blood vessels can be very challenging, and accidental intra-neural or intra-vascular injections can result in significant complications. Multi-spectral photoacoustic imaging can provide high sensitivity and specificity for discriminating hemoglobin-and lipid-rich tissues. However, conventional surface-illumination-based photoacoustic systems suffer from limited sensitivity at large depths. In this study, for the first time, an interventional multispectral photoacoustic imaging (IMPA) system was used to image nerves in a swine model in vivo. Pulsed excitation light with wavelengths in the ranges of 750-900 nm and 1150-1300 nm was delivered inside the body through an optical fiber positioned within the cannula of an injection needle. Ultrasound waves were received at the tissue surface using a clinical linear array imaging probe. Co-registered B-mode ultrasound images were acquired using the same imaging probe. Nerve identification was performed using a combination of B-mode ultrasound imaging and electrical stimulation. Using a linear model, spectral-unmixing of the photoacoustic data was performed to provide image contrast for oxygenated and de-oxygenated hemoglobin, water and lipids. Good correspondence between a known nerve location and a lipid-rich region in the photoacoustic images was observed. The results indicate that IMPA is a promising modality for guiding nerve blocks and other interventional procedures. Challenges involved with clinical translation are discussed.

Type: Proceedings paper
Title: Interventional multispectral photoacoustic imaging with a clinical linear array ultrasound probe for guiding nerve blocks
Event: Photons Plus Ultrasound: Imaging and Sensing 2016 - San Francisco, California, United States, 13 February 2016
ISBN-13: 9781628419429
Open access status: An open access version is available from UCL Discovery
DOI: 10.1117/12.2209047
Publisher version: http://dx.doi.org/10.1117/12.2209047
Language: English
Additional information: Copyright © 2016 Society of Photo-Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited.
Keywords: Photoacoustic imaging; Ultrasound imaging; Spectroscopy; Nerve blocks; Medical device guidance
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1478254
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