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Analysis of blink dynamics in patients with blepharoptosis

Mak, FH; Harker, A; Kwon, KA; Edirisinghe, M; Rose, GE; Murta, F; Ezra, DG; (2016) Analysis of blink dynamics in patients with blepharoptosis. Journal of the Royal Society Interface , 13 (116) , Article 0932. 10.1098/rsif.2015.0932. Green open access

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Abstract

Owing to the rapid movements of the human upper eyelid, a high-speed camera was used to record and characterize voluntary blinking and the blink dynamics of blepharoptosis patients were compared to a control group. Twenty-six blepharoptosis patients prior to surgery and 45 control subjects were studied and the vertical height of the palpebral aperture (PA) was measured manually at 2 ms intervals during each blink cycle. The PA and blinking speed were plotted with respect to time and a predictive model was generated. The blink dynamic was analysed in closing and opening phases, and revealed a reduced speed of the initial opening phase in ptotic patients, suggesting intrinsic muscle function change in ptosis pathogenesis. The PA versus time curve for each subject was reconstructed using custom-built parameters; however, there were significant differences between the two groups. Those parameters used included the rate of closure, the delay between opening and closing, rate of initial opening, rate of slow opening (nonlinear function) and the 'switch point' between those two rates of opening. The model was tested against a new group of subjects and was able to discriminate ptosis patients from controls with 80% accuracy.

Type: Article
Title: Analysis of blink dynamics in patients with blepharoptosis
Location: England
Open access status: An open access version is available from UCL Discovery
DOI: 10.1098/rsif.2015.0932
Publisher version: http://dx.doi.org/10.1098/rsif.2015.0932
Language: English
Additional information: Copyright © 2016 The Author(s) Published by the Royal Society. All rights reserved. The published article (Mak FHW, Harker A, Kwon K-A, Edirisinghe M, Rose GE, Murta F, Ezra DG. 2016 Analysis of blink dynamics in patients with blepharoptosis. J. R. Soc. Interface 13: 20150932) is available from the Journal of the Royal Society Interface website at http://dx.doi.org/10.1098/rsif.2015.0932)
Keywords: Blepharoptosis, blink dynamics, blinking, ptosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > Institute of Ophthalmology
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Maths and Physical Sciences > Dept of Physics and Astronomy
URI: https://discovery.ucl.ac.uk/id/eprint/1478087
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