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Behavioral training promotes multiple adaptive processes following acute hearing loss

Keating, P; Rosenior-Patten, O; Dahmen, JC; Bell, O; King, AJ; (2016) Behavioral training promotes multiple adaptive processes following acute hearing loss. eLife , 5 , Article 12264. 10.7554/eLife.12264. Green open access

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Abstract

The brain possesses a remarkable capacity to compensate for changes in inputs resulting from a range of sensory impairments. Developmental studies of sound localization have shown that adaptation to asymmetric hearing loss can be achieved either by reinterpreting altered spatial cues or by relying more on those cues that remain intact. Adaptation to monaural deprivation in adulthood is also possible, but appears to lack such flexibility. Here we show, however, that appropriate behavioral training enables monaurally-deprived adult humans to exploit both of these adaptive processes. Moreover, cortical recordings in ferrets reared with asymmetric hearing loss suggest that these forms of plasticity have distinct neural substrates. An ability to adapt to asymmetric hearing loss using multiple adaptive processes is therefore shared by different species and may persist throughout the lifespan. This highlights the fundamental flexibility of neural systems, and may also point toward novel therapeutic strategies for treating sensory disorders.

Type: Article
Title: Behavioral training promotes multiple adaptive processes following acute hearing loss
Open access status: An open access version is available from UCL Discovery
DOI: 10.7554/eLife.12264
Publisher version: http://dx.doi.org/10.7554/eLife.12264
Language: English
Additional information: Copyright © 2016 eLife Sciences Publications Ltd. Subject to a Creative Commons Attribution license, except where otherwise noted.
Keywords: Human, neuroscience
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > The Ear Institute
URI: https://discovery.ucl.ac.uk/id/eprint/1477575
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