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Applications of nanomaterials in mechano-sensitive tissues

Griffin, M; Kalaskar, D; (2016) Applications of nanomaterials in mechano-sensitive tissues. In: Nanomaterials and Regenerative Medicine. (pp. 385-416). IAPC-OBC Publishing: Zagreb, Croatia. Green open access

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Abstract

Bone, cartilage and tendon defects have specific structural, chemical and biological compositions. The extracellular matrix (ECM) of these musculoskeletal tissues interacts with cells to guide tissue formation. Since the ECM of such tissues is at the nanoscale, scaffolds in development are being developed which can mimic these structure. The structural features of the scaffolds affects cell adhesion, proliferation and differentiation. In order to repair musculoskeletal defects of bone, cartilage or tendon, synthetic materials are widely used. It is important that such materials must mimic the natural environment and provide an optimal matrix environment, biological properties including appropriate chemical cues such as growth factors and optimal mechanical properties to guide tissue regeneration. This chapter provides an overview of the properties of nanomaterials for bone, cartilage and tendon regeneration. It covers the aspects of incorporating nanoparticles with scaffolds to improve mechanical properties and the biocompatibility of polymers. The design, fabrication, challenges and success of incorporating of growth factors, genetic cues and drugs to enhance mechano-sentesive tissue has been provided with concluding remarkes on the future challenges and directions of nanomaterials for musculoskeletal tissues.

Type: Book chapter
Title: Applications of nanomaterials in mechano-sensitive tissues
ISBN-13: 978-953-56942-3-6
Open access status: An open access version is available from UCL Discovery
DOI: 10.5599/obp.9.0
Publisher version: http://iapc-obp.com/books/release_detail/9
Additional information: © 2016 by the authors; licensee IAPC, Zagreb, Croatia. This book is an open-access book distributed under the terms and conditions of the Creative Commons Attribution license.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Surgery and Interventional Sci > Department of Ortho and MSK Science
URI: https://discovery.ucl.ac.uk/id/eprint/1477008
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