UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

The Importance of Stochastic Effects for Explaining Entrainment in the Zebrafish Circadian Clock

Heussen, R; Whitmore, D; (2015) The Importance of Stochastic Effects for Explaining Entrainment in the Zebrafish Circadian Clock. Computational and Mathematical Methods in Medicine , 2015 , Article 254979. 10.1155/2015/254979. Green open access

[thumbnail of The Importance of Stochastic Effects for Explaining Entrainment in the Zebrafish Circadian Clock.pdf]
Preview
Text
The Importance of Stochastic Effects for Explaining Entrainment in the Zebrafish Circadian Clock.pdf - Published Version

Download (4MB) | Preview

Abstract

The circadian clock plays a pivotal role in modulating physiological processes and has been implicated, either directly or indirectly, in a range of pathological states including cancer. Here we investigate how the circadian clock is entrained by external cues such as light. Working with zebrafish cell lines and combining light pulse experiments with simulation efforts focused on the role of synchronization effects, we find that even very modest doses of light exposure are sufficient to trigger some entrainment, whereby a higher light intensity or duration correlates with strength of the circadian signal. Moreover, we observe in the simulations that stochastic effects may be considered an essential feature of the circadian clock in order to explain the circadian signal decay in prolonged darkness, as well as light initiated resynchronization as a strong component of entrainment.

Type: Article
Title: The Importance of Stochastic Effects for Explaining Entrainment in the Zebrafish Circadian Clock
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1155/2015/254979
Publisher version: http://dx.doi.org/10.1155/2015/254979
Language: English
Additional information: Copyright © 2015 Raphaela Heussen and David Whitmore. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology
URI: https://discovery.ucl.ac.uk/id/eprint/1476686
Downloads since deposit
65Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item