Heussen, R;
Whitmore, D;
(2015)
The Importance of Stochastic Effects for Explaining Entrainment in the Zebrafish Circadian Clock.
Computational and Mathematical Methods in Medicine
, 2015
, Article 254979. 10.1155/2015/254979.
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Abstract
The circadian clock plays a pivotal role in modulating physiological processes and has been implicated, either directly or indirectly, in a range of pathological states including cancer. Here we investigate how the circadian clock is entrained by external cues such as light. Working with zebrafish cell lines and combining light pulse experiments with simulation efforts focused on the role of synchronization effects, we find that even very modest doses of light exposure are sufficient to trigger some entrainment, whereby a higher light intensity or duration correlates with strength of the circadian signal. Moreover, we observe in the simulations that stochastic effects may be considered an essential feature of the circadian clock in order to explain the circadian signal decay in prolonged darkness, as well as light initiated resynchronization as a strong component of entrainment.
| Type: | Article |
|---|---|
| Title: | The Importance of Stochastic Effects for Explaining Entrainment in the Zebrafish Circadian Clock |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1155/2015/254979 |
| Publisher version: | http://dx.doi.org/10.1155/2015/254979 |
| Language: | English |
| Additional information: | Copyright © 2015 Raphaela Heussen and David Whitmore. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > Div of Biosciences > Cell and Developmental Biology |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1476686 |
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