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Natural variability of lung function in young healthy school children

Kirkby, J; Bountziouka, V; Lum, S; Wade, A; Stocks, J; (2016) Natural variability of lung function in young healthy school children. European Respiratory Journal , 48 (2) pp. 411-419. 10.1183/13993003.01795-2015. Green open access

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Abstract

Background: Knowledge about long-term variability of lung function in healthy children is essential when monitoring and treating those with respiratory disease over time. Aim: To define the natural variability in spirometry in young children after an interval of twelve months. Methods: The Size and Lung function In Children (SLIC) study was a prospective study designed to assess spirometry and body size, shape and composition in a multi-ethnic population of London school children. Fourteen schools with a wide range of socio-economic circumstances were recruited. Spirometric and anthropometric assessments and parental questionnaires pertaining to respiratory symptoms, previous medical history, pubertal status and socio-economic circumstances were completed at baseline and ~one year later. Findings: Technically acceptable spirometry data on two occasions ~1y apart (range: 9-16months) were available in 758 children (39% boys, mean (SD) age:8.1(1.6)y), 593 of whom were classified as ‘healthy’. Mean (SD) within-subject between-test variability was 0.05 (0.6) z-scores, with 95% of all the children achieving a between-test variability within ±1.2z-scores (equating to ~13%predicted). Interpretation: Natural variations of at least 1.2z-scores occur in healthy children over ~1y. These must be considered when interpreting results from annual reviews in those with lung disease who are otherwise stable if unnecessary further investigations or changes in treatment are to be avoided.

Type: Article
Title: Natural variability of lung function in young healthy school children
Location: UK
Open access status: An open access version is available from UCL Discovery
DOI: 10.1183/13993003.01795-2015
Publisher version: http://dx.doi.org/10.1183/13993003.01795-2015
Language: English
Additional information: This is an author-submitted, peer-reviewed version of a manuscript that has been accepted for publication in the European Respiratory Journal, prior to copy-editing, formatting and typesetting. This version of the manuscript may not be duplicated or reproduced without prior permission from the copyright owner, the European Respiratory Society. The publisher is not responsible or liable for any errors or omissions in this version of the manuscript or in any version derived from it by any other parties. The final, copy-edited, published article, which is the version of record, is available without a subscription 18 months after the date of issue publication.
Keywords: Paediatric, spirometry, health, variability
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Infection, Immunity and Inflammation Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
URI: https://discovery.ucl.ac.uk/id/eprint/1475954
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