Illangakoon, UE;
(2016)
Advanced drug delivery systems prepared by electrospinning.
Doctoral thesis , UCL (University College London).
Abstract
This thesis describes fast dissolving and sustained release drug delivery systems prepared using electrospinning. Chapter 1 provides a detailed literature review, and Chapter 2 gives details of the materials and methods used. Chapter 3 details the preparation of fibers of poly(vinyl pyrrolidone) (PVP) and Eudragit L100-55 loaded with mebeverine hydrochloride, a drug used to treat irritable bowel syndrome. The drug was amorphously distributed in the fibers. The PVP based fibers dissolved very quickly (within 10s) when added to an aqueous medium, while Eudragit L100-55 fibers were able to retard drug release in acidic environments representative of the stomach and provide sustained release in media representative of the lower parts of the gastro-intestinal tract. Chapter 4 explores the generation of fast dissolving paracetamol/caffeine/PVP fibres for use as paediatric formulations. A flavouring agent was also incorporated. The fiber mats disintegrated in around 300 ms, and freed all the embedded drug into solution by 2 min. In Chapter 5, fibers were prepared in which the anti-cancer drug fluorouracil (5-FU) was combined with PVP, a phospholipid and cholesterol or trehalose. When added to water, the components of the fibers self-assembled to form drug-loaded liposomes. Although the inclusion of cholesterol and trehalose was observed to have an effect on the liposome size and surface charge, the drug release properties were essentially the same for all the formulations. In Chapter 6, fast-dissolving 5-FU nanofibers were first prepared with PVP. The mats showed cytotoxicity towards a leukaemia cell line, but not to a prostate cancer cell line. Fibers were of 5-FU and Eudragit L100-55 and S100 were also generated. Monolithic fibers gave considerable release at pH1.0. Core/shell fibers with a Eudragit S100 shell and 5-FU in the core ameliorated this issue to some extent, but considerable release at pH 1.0 was still observed.
| Type: | Thesis (Doctoral) |
|---|---|
| Title: | Advanced drug delivery systems prepared by electrospinning |
| Event: | UCL |
| Language: | English |
| Keywords: | Electrospinning, Drug delivery |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1474058 |
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