Yu, DG;
Yang, C;
Jin, M;
Williams, GR;
Zou, H;
Wang, X;
Annie Bligh, SW;
(2015)
Medicated Janus fibers fabricated using a Teflon-coated side-by-side spinneret.
Colloids and Surfaces B: Biointerfaces
, 138
pp. 110-116.
10.1016/j.colsurfb.2015.11.055.
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Abstract
A family of medicated Janus fibers that provides highly tunable biphasic drug release was fabricated using a side-by-side electrospinning process employing a Teflon-coated parallel spinneret. The coated spinneret facilitated the formation of a Janus Taylor cone and in turn high quality integrated Janus structures, which could not be reliably obtained without the Teflon coating. The fibers prepared had one side consisting of polyvinylpyrrolidone (PVP) K60 and ketoprofen, and the other of ethyl cellulose (EC) and ketoprofen. To modulate and tune drug release, PVP K10 was doped into the EC side in some cases. The fibers were linear and had flat morphologies with an indent in the center. They provide biphasic drug release, with the PVP K60 side dissolving very rapidly to deliver a loading dose of the active ingredient, and the EC side resulting in sustained release of the remaining ketoprofen. The addition of PVP K10 to the EC side was able to accelerate the second stage of release; variation in the dopant amount permitted the release rate and extent this phase to be precisely tuned. These results offer the potential to rationally design systems with highly controllable drug release profiles, which can complement natural biological rhythms and deliver maximum therapeutic effects.
| Type: | Article |
|---|---|
| Title: | Medicated Janus fibers fabricated using a Teflon-coated side-by-side spinneret. |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.colsurfb.2015.11.055 |
| Publisher version: | http://dx.doi.org/10.1016/j.colsurfb.2015.11.055 |
| Language: | English |
| Additional information: | © 2015 Elsevier B.V. This manuscript version is made available under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International license (CC BY-NC-ND 4.0). This license allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licenses are available at http://creativecommons.org/ licenses/by/4.0. Access may be initially restricted by the publisher. |
| Keywords: | Janus fibers, Nano drug delivery systems, Side-by-side electrospinning, Structural nanocomposites, Teflon-coated spinneret, Tunable release rates |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Life Sciences > UCL School of Pharmacy > Pharmaceutics |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1473811 |
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