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Investigating cerebral oedema using poroelasticity

Vardakis, IC; Chou, D; Tully, BJ; Hung, CC; Lee, TH; Tsui, PH; Ventikos, Y; (2016) Investigating cerebral oedema using poroelasticity. Medical Engineering and Physics , 38 (1) pp. 48-57. 10.1016/j.medengphy.2015.09.006. Green open access

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Abstract

Cerebral oedema can be classified as the tangible swelling produced by expansion of the interstitial fluid volume. Hydrocephalus can be succinctly described as the abnormal accumulation of cerebrospinal fluid (CSF) within the brain which ultimately leads to oedema within specific sites of parenchymal tissue. Using hydrocephalus as a test bed, one is able to account for the necessary mechanisms involved in the interaction between oedema formation and cerebral fluid production, transport and drainage. The current state of knowledge about integrative cerebral dynamics and transport phenomena indicates that poroelastic theory may provide a suitable framework to better understand various diseases. In this work, Multiple-Network Poroelastic Theory (MPET) is used to develop a novel spatio-temporal model of fluid regulation and tissue displacement within the various scales of the cerebral environment. The model is applied through two formats, a one-dimensional finite difference – Computational Fluid Dynamics (CFD) coupling framework, as well as a two-dimensional Finite Element Method (FEM) formulation. These are used to investigate the role of endoscopic fourth ventriculostomy in alleviating oedema formation due to fourth ventricle outlet obstruction (1D coupled model) in addition to observing the capability of the FEM template in capturing important characteristics allied to oedema formation, like for instance in the periventricular region (2D model).

Type: Article
Title: Investigating cerebral oedema using poroelasticity
Location: UK
Open access status: An open access version is available from UCL Discovery
DOI: 10.1016/j.medengphy.2015.09.006
Publisher version: http://dx.doi.org/10.1016/j.medengphy.2015.09.006
Language: English
Additional information: © 2015 The Authors. Published by Elsevier Ltd on behalf of IPEM. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Keywords: Cerebral oedema, Multiple-Network Poroelastic Theory, Hydrocephalus, Computational Fluid Dynamics, Finite Element Method, Intracranial Pressure, Aquaporins, Endoscopic ventriculostomy, Fourth Ventricular Outlet Obstruction, Periventricular lucency, Gliosis
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering
URI: https://discovery.ucl.ac.uk/id/eprint/1473592
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