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Maximum-Likelihood Joint Image Reconstruction/Motion Estimation in Attenuation-Corrected Respiratory Gated PET/CT using a Single Attenuation Map

Bousse, A; Bertolli, O; Atkinson, D; Arridge, S; Ourselin, S; Hutton, B; Thielemans, K; (2015) Maximum-Likelihood Joint Image Reconstruction/Motion Estimation in Attenuation-Corrected Respiratory Gated PET/CT using a Single Attenuation Map. IEEE Trans Med Imaging , 35 (1) pp. 217-228. 10.1109/TMI.2015.2464156. Green open access

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Abstract

This work provides an insight into positron emission tomography (PET) joint image reconstruction/motion estimation (JRM) by maximization of the likelihood, where the probabilistic model accounts for warped attenuation. Our analysis shows that maximum-likelihood (ML) JRM returns the same reconstructed gates for any attenuation map (-map) that is a deformation of a given -map, regardless of its alignment with the PET gates. We derived a joint optimization algorithm accordingly, and applied it to simulated and patient gated PET data. We first evaluated the proposed algorithm on simulations of respiratory gated PET/CT data based on the XCAT phantom. Our results show that independently of which -map is used as input to JRM: (i) the warped -maps correspond to the gated -maps, (ii) JRM outperforms the traditional post-registration reconstruction and consolidation (PRRC) for hot lesion quantification and (iii) reconstructed gated PET images are similar to those obtained with gated -maps. This suggests that a breath-held -map can be used. We then applied JRM on patient data with a - map derived from a breath-held high resolution CT (HRCT), and compared the results with PRRC, where each reconstructed PET image was obtained with a corresponding cine-CT gated - map. Results show that JRM with breath-held HRCT achieves similar reconstruction to that using PRRC with cine-CT. This suggests a practical low-dose solution for implementation of motion-corrected respiratory gated PET/CT.

Type: Article
Title: Maximum-Likelihood Joint Image Reconstruction/Motion Estimation in Attenuation-Corrected Respiratory Gated PET/CT using a Single Attenuation Map
Open access status: An open access version is available from UCL Discovery
DOI: 10.1109/TMI.2015.2464156
Publisher version: http://dx.doi.org/10.1109/TMI.2015.2464156
Language: English
Additional information: This work is licensed under a Creative Commons Attribution 3.0 License. For more information, see http://creativecommons.org/licenses/by/3.0/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Div of Medicine > Department of Imaging
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Computer Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1472959
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