Zamir, A;
Arthurs, O;
Hagen, CK;
Diemoz, PC;
Brochard, T;
Bravin, A;
Sebire, N;
(2015)
X-ray phase contrast tomography; proof of principle for post-mortem imaging.
British Journal of Radiology
, 89
(109)
, Article 20150565. 10.1259/bjr.20150565.
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Abstract
Objectives: To demonstrate the feasibility of using X-ray phase contrast tomography to assess internal organs in a post-mortem piglet model, as a possible non-invasive imaging autopsy technique. Methods: Tomographic images of a new-born piglet were obtained using a Free Space Propagation (FSP) X-ray phase contrast imaging setup at a synchrotron (European Synchrotron Radiation Facility, Grenoble, France). A monochromatic X-ray beam (52 keV) was used in combination with a detector pixel size of 46x46 μm2. A phase-retrieval algorithm was applied to all projections, which were then reconstructed into tomograms using the filtered-back projection algorithm. Images were assessed for diagnostic quality. Results: Images obtained with the FSP setup presented high soft tissue contrast and sufficient resolution for resolving organ structure. All of the main body organs (heart, lungs, kidneys, liver and intestines) were easily identified and adequately visualised. In addition, grey/white matter differentiation in the cerebellum while still contained within the skull was shown. Conclusions: The feasibility of using X-ray phase contrast tomography as a post-mortem imaging technique in an animal model has been demonstrated. Future studies will focus on translating this experiment to a laboratory-based setup.
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