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X-ray phase contrast tomography; proof of principle for post-mortem imaging

Zamir, A; Arthurs, O; Hagen, CK; Diemoz, PC; Brochard, T; Bravin, A; Sebire, N; (2015) X-ray phase contrast tomography; proof of principle for post-mortem imaging. British Journal of Radiology , 89 (109) , Article 20150565. 10.1259/bjr.20150565. Green open access

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Abstract

Objectives: To demonstrate the feasibility of using X-ray phase contrast tomography to assess internal organs in a post-mortem piglet model, as a possible non-invasive imaging autopsy technique. Methods: Tomographic images of a new-born piglet were obtained using a Free Space Propagation (FSP) X-ray phase contrast imaging setup at a synchrotron (European Synchrotron Radiation Facility, Grenoble, France). A monochromatic X-ray beam (52 keV) was used in combination with a detector pixel size of 46x46 μm2. A phase-retrieval algorithm was applied to all projections, which were then reconstructed into tomograms using the filtered-back projection algorithm. Images were assessed for diagnostic quality. Results: Images obtained with the FSP setup presented high soft tissue contrast and sufficient resolution for resolving organ structure. All of the main body organs (heart, lungs, kidneys, liver and intestines) were easily identified and adequately visualised. In addition, grey/white matter differentiation in the cerebellum while still contained within the skull was shown. Conclusions: The feasibility of using X-ray phase contrast tomography as a post-mortem imaging technique in an animal model has been demonstrated. Future studies will focus on translating this experiment to a laboratory-based setup.

Type: Article
Title: X-ray phase contrast tomography; proof of principle for post-mortem imaging
Location: UK
Open access status: An open access version is available from UCL Discovery
DOI: 10.1259/bjr.20150565
Publisher version: http://dx.doi.org/10.1259/bjr.20150565
Language: English
Additional information: © 2015 The Authors. Published by the British Institute of Radiology.
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Developmental Neurosciences Dept
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL GOS Institute of Child Health > Population, Policy and Practice Dept
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1472793
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