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No evidence for substrate accumulation in Parkinson brains with GBA mutations

Gegg, ME; Sweet, L; Wang, BH; Shihabuddin, LS; Sardi, SP; Schapira, AH; (2015) No evidence for substrate accumulation in Parkinson brains with GBA mutations. Movement Disorders , 30 (8) pp. 1085-1089. 10.1002/mds.26278. Green open access

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Abstract

To establish whether Parkinson's disease (PD) brains previously described to have decreased glucocerebrosidase activity exhibit accumulation of the lysosomal enzyme's substrate, glucosylceramide, or other changes in lipid composition.

Type: Article
Title: No evidence for substrate accumulation in Parkinson brains with GBA mutations
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1002/mds.26278
Publisher version: http://dx.doi.org/10.1002/mds.26278
Language: English
Additional information: © 2015 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Keywords: Parkinson's disease, glucocerebrosidase, lysosomes, sphingolipids
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences
URI: https://discovery.ucl.ac.uk/id/eprint/1471772
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