Gegg, ME;
Sweet, L;
Wang, BH;
Shihabuddin, LS;
Sardi, SP;
Schapira, AH;
(2015)
No evidence for substrate accumulation in Parkinson brains with GBA mutations.
Movement Disorders
, 30
(8)
pp. 1085-1089.
10.1002/mds.26278.
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Abstract
To establish whether Parkinson's disease (PD) brains previously described to have decreased glucocerebrosidase activity exhibit accumulation of the lysosomal enzyme's substrate, glucosylceramide, or other changes in lipid composition.
Type: | Article |
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Title: | No evidence for substrate accumulation in Parkinson brains with GBA mutations |
Location: | United States |
Open access status: | An open access version is available from UCL Discovery |
DOI: | 10.1002/mds.26278 |
Publisher version: | http://dx.doi.org/10.1002/mds.26278 |
Language: | English |
Additional information: | © 2015 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
Keywords: | Parkinson's disease, glucocerebrosidase, lysosomes, sphingolipids |
UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Clinical and Movement Neurosciences |
URI: | https://discovery.ucl.ac.uk/id/eprint/1471772 |
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