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Development of novel remineralising antibacterial dental composite

Dakkouri, LI; (2015) Development of novel remineralising antibacterial dental composite. Doctoral thesis , UCL (University College London). Green open access

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Abstract

The most common current cause of composite restoration failure is bacterial microleakage. This is the passage of bacteria between the tooth and restoration and results in continuing dentine de-mineralisation and disease. The aim of this study was therefore to develop a dental composite with re-mineralising and anti-bacterial components. Methods: Urethane dimethacrylate: poly(propylene glycol) dimethacryate (3:1) was mixed with 5 wt% 2-hydroxyethyl methacrylate, 1 wt% photoinitiator (camphorquinone), and 1 wt% accelerator (N(p-tolyl)glycine-glycidyl methacrylate). This was combined with dental glass particles mixed with anti-bacterial polylysine (0 or 5 wt%) and mono and tri calcium phosphate (each at 0 or 20 wt%) in a powder to liquid ratio of 4:1. Light cured composite discs (10 mm diameter, 1 mm thick, n=8) were prepared and stored dry, in distilled water (DW), simulated body fluid (SBF) or Artificial Saliva. Surfaces were examined by Scanning-electron microscopy (SEM), Energy-dispersive X-ray (EDX) spectroscopy and Raman microscopy after 7 days storage. Mass and volume changes in DW and SBF were determined gravimetrically at 12-weeks storage. Polylysine release into water was assessed using Trypan Blue dye and visible absorbance spectroscopy. Results: Various calcium phosphates precipitated on the material surfaces and cores but apatite was found only on the surface of samples containing both calcium phosphates and Polylysine that were stored in SBF. This formula showed greater increase in mass and volume change, and the highest Polylysine release. Composite containing both calcium phosphates (MCPM and TCP) and polylysine showed the highest water sorption potential and therefore more precipitation and increase in volume. Also, adding both MCPM and TCP slightly enhanced the release of the antibacterial (polylysine). Significance: Formulations with MCPM, TCP and polylysine through water sorption induced expansion; re-mineralisation and anti-bacterial release have potential to reduce recurrent caries.

Type: Thesis (Doctoral)
Title: Development of novel remineralising antibacterial dental composite
Event: UCL (University College London)
Open access status: An open access version is available from UCL Discovery
Language: English
Keywords: composite, restoration, remineralisation, anti-bacterial
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Eastman Dental Institute
URI: https://discovery.ucl.ac.uk/id/eprint/1471606
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