Xia, W;
Nikitichev, DI;
Mari, JM;
West, SJ;
Pratt, R;
David, AL;
Ourselin, S;
... Desjardins, AE; + view all
(2015)
Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures.
Journal of Biomedical Optics
, 20
(8)
, Article 086005. 10.1117/1.JBO.20.8.086005.
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Abstract
Precise device guidance is important for interventional procedures in many different clinical fields including fetal medicine, regional anesthesia, interventional pain management, and interventional oncology. While ultrasound is widely used in clinical practice for real-time guidance, the image contrast that it provides can be insufficient for visualizing tissue structures such as blood vessels, nerves, and tumors. This study was centered on the development of a photoacoustic imaging system for interventional procedures that delivered excitation light in the ranges of 750 to 900 nm and 1150 to 1300 nm, with an optical fiber positioned in a needle cannula. Coregistered B-mode ultrasound images were obtained. The system, which was based on a commercial ultrasound imaging scanner, has an axial resolution in the vicinity of 100 μm and a submillimeter, depth-dependent lateral resolution. Using a tissue phantom and 800 nm excitation light, a simulated blood vessel could be visualized at a maximum distance of 15 mm from the needle tip. Spectroscopic contrast for hemoglobin and lipids was observed with ex vivo tissue samples, with photoacoustic signal maxima consistent with the respective optical absorption spectra. The potential for further optimization of the system is discussed.
| Type: | Article |
|---|---|
| Title: | Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures. |
| Location: | United States |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/1.JBO.20.8.086005 |
| Publisher version: | http://dx.doi.org/10.1117/1.JBO.20.8.086005 |
| Language: | English |
| Additional information: | Xia W, Nikitichev DI, Mari J, et al; Performance characteristics of an interventional multispectral photoacoustic imaging system for guiding minimally invasive procedures. Journal of Biomedical Optics. 20 (8): 086005. doi:10.1117/1.JBO.20.8.086005. Copyright 2015 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/1.JBO.20.8.086005 |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > UCL EGA Institute for Womens Health > Maternal and Fetal Medicine UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1470672 |
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