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A longitudinal study of cortical grey matter lesion subtypes in relapse-onset multiple sclerosis

Sethi, V; Yousry, T; Muhlert, N; Tozer, DJ; Altmann, D; Ron, M; Wheeler-Kingshott, CAM; ... Chard, DT; + view all (2015) A longitudinal study of cortical grey matter lesion subtypes in relapse-onset multiple sclerosis. Journal of Neurology, Neurosurgery and Psychiatry , 87 pp. 750-753. 10.1136/jnnp-2015-311102. Green open access

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Abstract

Background: Cortical grey matter (GM) lesions are common in multiple sclerosis (MS), but little is known about their temporal evolution. We investigated this in people with relapsing-remitting (RR) and secondary progressive (SP) MS. Methods: 27 people with RRMS, and 22 with SPMS were included in this study. Phase sensitive inversion recovery (PSIR) scans were acquired on two occasions. Cortical GM lesions were classified as intracortical (IC, only involving GM) and leucocortical (LC, mixed GM-white matter [WM]); WM lesions touching the cortex as juxtacortical (JC). On follow up scans, new IC, LC and JC lesions were identified, and any change in classification of lesions previously observed was noted. WM lesion counts in the whole brain were assessed on PD/T2-weighted scans. Results: Over a mean (SD) of 21.0 (5.8) months, the number of new IC lesions per person per year was greater in SPMS (1.6 [1.9]) than RRMS (0.8 [1.9]) (Mann-Whitney p=0.039). All new LC lesions arose from previously seen IC lesions (SPMS 1.4 [1.8] per person per year, and RRMS 1.1 [1.0]), and none arose de novo or from previously seen JC lesions. Changes in cortical GM (either new IC or IC converting to LC) lesion counts did not correlate with the changes in WM lesion counts. Conclusions: New cortical GM lesions rarely arise from the WM and the rate of new IC lesion formation is not closely linked with WM lesion accrual. IC lesion formation appears to be more common in SPMS than RRMS.

Type: Article
Title: A longitudinal study of cortical grey matter lesion subtypes in relapse-onset multiple sclerosis
Location: UK
Open access status: An open access version is available from UCL Discovery
DOI: 10.1136/jnnp-2015-311102
Publisher version: http://dx.doi.org/10.1136/jnnp-2015-311102
Language: English
Additional information: This article has been accepted for publication in Journal of Neurology, Neurosurgery and Psychiatry following peer review. The final published version will be available from: http://jnnp.bmj.com/
UCL classification: UCL
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Brain Repair and Rehabilitation
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Department of Neuromuscular Diseases
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Brain Sciences > UCL Queen Square Institute of Neurology > Neuroinflammation
URI: https://discovery.ucl.ac.uk/id/eprint/1470345
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