Xia, W;
Nikitichev, DI;
Mari, JM;
West, SJ;
Ourselin, S;
Beard, PC;
Desjardins, AE;
(2015)
An interventional multispectral photoacoustic imaging platform for the guidance of minimally invasive procedures.
In: Ntziachristos, V and Zemp, R, (eds.)
Opto-Acoustic Methods and Applications in Biophotonics II: 22–23 June 2015 Munich, Germany.
(pp. 95390D).
SPIE: Bellingham WA, US.
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Abstract
Precise and efficient guidance of medical devices is of paramount importance for many minimally invasive procedures. These procedures include fetal interventions, tumor biopsies and treatments, central venous catheterisations and peripheral nerve blocks. Ultrasound imaging is commonly used for guidance, but it often provides insufficient contrast with which to identify soft tissue structures such as vessels, tumors, and nerves. In this study, a hybrid interventional imaging system that combines ultrasound imaging and multispectral photoacoustic imaging for guiding minimally invasive procedures was developed and characterized. The system provides both structural information from ultrasound imaging and molecular information from multispectral photoacoustic imaging. It uses a commercial linear-array ultrasound imaging probe as the ultrasound receiver, with a multimode optical fiber embedded in a needle to deliver pulsed excitation light to tissue. Co-registration of ultrasound and photoacoustic images is achieved with the use of the same ultrasound receiver for both modalities. Using tissue ex vivo, the system successfully discriminated deep-located fat tissue from the surrounding muscle tissue. The measured photoacoustic spectrum of the fat tissue had good agreement with the lipid spectrum in literature.
| Type: | Proceedings paper |
|---|---|
| Title: | An interventional multispectral photoacoustic imaging platform for the guidance of minimally invasive procedures |
| Event: | Opto-Acoustic Methods and Applications in Biophotonics II |
| Location: | Munich, Germany |
| Dates: | 21 June 2015 |
| ISBN-13: | 9781628417043 |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1117/12.2183798 |
| Publisher version: | http://dx.doi.org/10.1117/12.2183798 |
| Language: | English |
| Additional information: | Wenfeng Xia ; Daniil I. Nikitichev ; Jean Martial Mari ; Simeon J. West ; Sebastien Ourselin ; Paul C. Beard ; Adrien E. Desjardins; An interventional multispectral photoacoustic imaging platform for the guidance of minimally invasive procedures. Proceedings of SPIE 9539, Opto-Acoustic Methods and Applications in Biophotonics II, 95390D (July 16, 2015); doi:10.1117/12.2183798. Copyright 2015 Society of Photo Optical Instrumentation Engineers. One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper are prohibited. http://dx.doi.org/10.1117/12.2183798 |
| Keywords: | Fiber optic, Minimally invasive procedures, Photoacoustic imaging, Ultrasonic tracking, Ultrasound imaging |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Mechanical Engineering UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1470327 |
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