UCL Discovery
UCL home » Library Services » Electronic resources » UCL Discovery

Improving the outcomes for high-­risk neuroblastoma through the optimisation of radiotherapeutic techniques

Gains, JE; (2015) Improving the outcomes for high-­risk neuroblastoma through the optimisation of radiotherapeutic techniques. Doctoral thesis , UCL (University College London). Green open access

[thumbnail of Gains. complete thesis.pdf]
Preview
Text
Gains. complete thesis.pdf

Download (30MB) | Preview

Abstract

Neuroblastoma is a childhood cancer with highly variable clinical behaviour and outcomes. The long-­‐term survival rate for high-­‐risk neuroblastoma remains poor and new therapeutic advances and optimisation of existing therapies is therefore required. Both external beam radiotherapy and molecular radiotherapy have a significant role to play in the multi-­‐modality treatment of high-­‐risk disease. This collection of work examines ways in which the outcome for neuroblastoma may be improved through the introduction of new and enhancement of existing radiotherapeutic techniques. 131I-­‐meta-­‐Iodobenzylguanidine molecular radiotherapy has been used in the treatment of neuroblastoma since the mid 1980’s. Despite this, its role and efficacy remain undefined. A systematic review of 131I-­‐mIBG therapy in neuroblastoma is therefore presented. Radiolabelled somatostatin analogues target a distinct and separate molecular target on neuroblastoma cells to the noradrenaline transporter targeted by 131I-­‐mIBG. This study reports on the use of radiolabelled somatostatin analogues for the imaging and therapy of patients with high-­‐risk neuroblastoma. The expression of the two different molecular targets by immunohistochemistry for the noradrenaline transporter molecule and somatostatin receptor type-­‐2 in archived neuroblastoma tumour samples is also explored. The radiation doses received by comforters and carers providing necessary support to children undergoing molecular radiotherapy over a 10 year period is presented. The gold standard imaging modality for response assessment in neuroblastoma is 123I-­‐mIBG scinitgraphy. The role of other functional imaging techniques such as 18F-­‐ FDG PET/CT remains undefined. This study will look to see if 18F-­‐FDG PET/CT can give additional information with regards to response assessment. External beam radiotherapy is standardly delivered using conventional anterior and posterior parallel opposed beams and this can result in a compromise on target volume coverage to stay within the tolerance of normal tissues. The use of an Intensity Modulated Arc Therapy technique to improve target volume coverage is examined.

Type: Thesis (Doctoral)
Title: Improving the outcomes for high-­risk neuroblastoma through the optimisation of radiotherapeutic techniques
Event: UCL (University College London)
Open access status: An open access version is available from UCL Discovery
Language: English
UCL classification: UCL
UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Medical Sciences > Cancer Institute > Research Department of Oncology
URI: https://discovery.ucl.ac.uk/id/eprint/1470162
Downloads since deposit
348Downloads
Download activity - last month
Download activity - last 12 months
Downloads by country - last 12 months

Archive Staff Only

View Item View Item