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Electrical Impedance Tomography of Fast Neural Activity In The Brain

Ghosh, A; (2015) Electrical Impedance Tomography of Fast Neural Activity In The Brain. Doctoral thesis , UCL(University College London). Green open access

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Abstract

Electrical impedance tomography (EIT) is a recently developed imaging method that can be used to reconstruct the internal conductivity of a body from boundary measurements. A proposed application of EIT within head imaging is functional brain imaging. The work of this thesis was aimed specifically at producing images of fast neuronal depolarisation in the brain. Chapter 1 is a review of other brain imaging techniques, the principles of EIT and bioimpedance and nerve physiology. Chapter 2 was a study to verify previous work on measuring the impedance change in unmyelinated crab nerves using a DC carrier. Chapter 3 was a study aimed at using a low frequency sinusoidal wave carrier to do the same and in chapter 4 the same carrier was used to measure the impedance change during evoked responses on the anaesthetised rat cerebral cortex and identify the optimum frequency and current to be used to reconstruct images. Chapter 5 details experiments to image fast neuronal activity in rat cerebral cortex of different evoked sensory modalities (vibrissae, forepaw, hindpaw sensation and visual responses) using the above carrier.

Type: Thesis (Doctoral)
Title: Electrical Impedance Tomography of Fast Neural Activity In The Brain
Open access status: An open access version is available from UCL Discovery
Language: English
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > UCL BEAMS
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science
UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng
URI: https://discovery.ucl.ac.uk/id/eprint/1470136
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