Millard, TP;
Endrizzi, M;
Everdell, N;
Rigon, L;
Arfelli, F;
Menk, RH;
Stride, E;
(2015)
Evaluation of microbubble contrast agents for dynamic imaging with x-ray phase contrast.
Scientific Reports
, 5
, Article 12509. 10.1038/srep12509.
![[thumbnail of srep12509.pdf]](https://discovery.ucl.ac.uk/style/images/fileicons/text.png) |
Text
srep12509.pdf Download (789kB) |
Abstract
X-rays are commonly used as a means to image the inside of objects opaque to visible light, as their short wavelength allows penetration through matter and the formation of high spatial resolution images. This physical effect has found particular importance in medicine where x-ray based imaging is routinely used as a diagnostic tool. Increasingly, however, imaging modalities that provide functional as well as morphological information are required. In this study the potential to use x-ray phase based imaging as a functional modality through the use of microbubbles that can be targeted to specific biological processes is explored. We show that the concentration of a microbubble suspension can be monitored quantitatively whilst in flow using x-ray phase contrast imaging. This could provide the basis for a dynamic imaging technique that combines the tissue penetration, spatial resolution, and high contrast of x-ray phase based imaging with the functional information offered by targeted imaging modalities.
| Type: | Article |
|---|---|
| Title: | Evaluation of microbubble contrast agents for dynamic imaging with x-ray phase contrast |
| Location: | UK |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1038/srep12509 |
| Publisher version: | http://dx.doi.org/10.1038/srep12509 |
| Language: | English |
| Additional information: | This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > UCL BEAMS UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science UCL > Provost and Vice Provost Offices > UCL BEAMS > Faculty of Engineering Science > Dept of Med Phys and Biomedical Eng |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1469656 |
Archive Staff Only
 |
View Item |
