De Luca, Laura; Westbrook, Rachel; Tsochatzis, Emmanuel A; (2015) Metabolic and cardiovascular complications in the liver transplant recipient. Annals of Gastroenterology , 28 (2) 182 - 192.

Text de Luca, Metabolic and cardiovascular complications, AnnGastroenterol-28-182.pdf Download (216kB)

Abstract

Metabolic syndrome (MS) is an established risk factor for atherosclerosis and cardiovascular disease that affects 20-30% of the adult population in the western world, correlating with increased incidence of cardiovascular disease. Survival following liver transplantation (LT) has been steadily improving over the last 2 decades, with graft loss becoming a relatively rare cause of morbidity and mortality post LT. The improvement in short-term survival following LT has resulted in an increased incidence of metabolic and cardiovascular complications, which affect the mid-and long term survival. Patients following LT typically gain weight and might develop diabetes, hypertension and dyslipidemia as a consequence of their immunosuppressive therapy and their lifestyle. In this paper we review the prevalence of metabolic and cardiovascular complications following LT, their impact on post-transplant morbidity and mortality and their optimal management.

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