Lichman, BR;
Lamming, ED;
Pesnot, T;
Smith, JM;
Hailes, HC;
Ward, JM;
(2015)
One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine.
Green Chemistry
, 17
(2)
pp. 852-855.
10.1039/c4gc02325k.
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Abstract
We describe novel chemoenzymatic routes to (S)-benzylisoquinoline and (S)-tetrahydroprotoberberine alkaloids using the enzymes transaminase (TAm) and norcoclaurine synthase (NCS) in a one-pot, one-substrate ‘triangular’ cascade. Employment of up to two C–C bond forming steps allows for the rapid generation of molecular complexity under mild conditions.
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