Hughes, AD;
(2015)
Optimality, cost minimization and the design of arterial networks.
Artery Research
, 10
pp. 1-10.
10.1016/j.artres.2015.01.001.
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Abstract
The arterial circulation acts as a network to deliver nutrients and oxygen to cells. The design of the cardiovascular system is subject to a variety of constraints and costs. It has been postulated that the design of the arterial network might be understood in terms of the need to minimize competing 'costs' within the context of physical or material limits to the system. These designs can also be envisaged as being subservient to space filling or fractal considerations. The signalling mechanisms underlying these designs remain to be fully characterized although shear stress, wall tensile stress and metabolic stimuli are likely candidates. I will also review evidence that deviations from a minimal cost condition or optimal design may provide both a measure of disease severity and insights into the underlying disease mechanism.
| Type: | Article |
|---|---|
| Title: | Optimality, cost minimization and the design of arterial networks |
| Open access status: | An open access version is available from UCL Discovery |
| DOI: | 10.1016/j.artres.2015.01.001 |
| Publisher version: | http://dx.doi.org/10.1016/j.artres.2015.01.001 |
| Language: | English |
| Additional information: | Copyright © 2015. This manuscript version is published under a Creative Commons Attribution Non-commercial Non-derivative 4.0 International licence (CC BY-NC-ND 4.0). This licence allows you to share, copy, distribute and transmit the work for personal and non-commercial use providing author and publisher attribution is clearly stated. Further details about CC BY licences are available at http://creativecommons.org/licenses/by/4.0. |
| Keywords: | Circulation; Design; Optimality; Shear stress |
| UCL classification: | UCL UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Population Health Sciences > Institute of Cardiovascular Science > Population Science and Experimental Medicine |
| URI: | https://discovery.ucl.ac.uk/id/eprint/1463736 |
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