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Genetic risk factors and Mendelian randomization in cardiovascular disease

Swerdlow, DI; Hingorani, AD; Humphries, SE; (2015) Genetic risk factors and Mendelian randomization in cardiovascular disease. Current Cardiology Reports , 17 (5) , Article 33. 10.1007/s11886-015-0584-x. Green open access

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Abstract

Cardiovascular disease encompasses several diverse pathological states that place a heavy burden on individual and population health. The aetiological basis of many cardiovascular disorders is not fully understood. Growing knowledge of the genetic architecture underlying coronary heart disease, stroke, cardiac arrhythmias and peripheral vascular disease has confirmed some suspected causal pathways in these conditions but also uncovered many previously unknown mechanisms. Here, we consider the contribution of genetics to the understanding of cardiovascular disease risk. We evaluate the utility and relevance of findings from genome-wide association studies and explore the role that Mendelian randomisation has to play in exploiting these. Mendelian randomisation permits robust causal inference in an area of research where this has been hampered by bias and confounding in observational studies. In doing so, it provides evidence for causal processes in cardiovascular disease that could represent novel targets for much-needed new drugs for disease prevention and treatment.

Type: Article
Title: Genetic risk factors and Mendelian randomization in cardiovascular disease
Location: United States
Open access status: An open access version is available from UCL Discovery
DOI: 10.1007/s11886-015-0584-x
Publisher version: http://dx.doi.org/10.1007/s11886-015-0584-x
Language: English
Additional information: The final publication is available at Springer via http://dx.doi.org/10.1007/s11886-015-0584-x.
Keywords: Cardiovascular disease, Genetics, Risk factors, Mendelian randomisation, Causal inference, Risk prediction
UCL classification: UCL > Provost and Vice Provost Offices
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences
UCL > Provost and Vice Provost Offices > School of Life and Medical Sciences > Faculty of Pop Health Sciences > Institute of Cardiovascular Science
URI: https://discovery.ucl.ac.uk/id/eprint/1462717
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